Learn More
Methylglyoxal (MG) is a ubiquitous metabolite derived from glycolysis; however, this aldehyde kills all types of cell. We analyzed the properties of MG-induced cell death of the budding yeast Saccharomyces cerevisiae. The MCA1 gene encodes a caspase homologue that is involved in H2O2-induced apoptosis in yeast, although the disruption of MCA1 did not(More)
To date, parathyroid hormone is the only clinically available bone anabolic drug. The major difficulty in the development of such drugs is the lack of clarification of the mechanisms regulating osteoblast differentiation and bone formation. Here, we report a peptide (W9) known to abrogate osteoclast differentiation in vivo via blocking receptor activator of(More)
(A) Binding and potency of 100 ng/mL OYC1 or OYC2 were detected by ELISA with various concentrations of recombinant mouse sRANKL (mRANKL). (B) Inhibitory activity of OYC1 in a TRAP solution assay. RAW264 cells were cultured for 4 days in the presence of 5 nM mRANKL with or without 0.025-1.0 μg/mL OYC1, 1.0 μg/mL OYC2, or 0.1 μg/mL of OPG-Fc. The cells were(More)
  • 1