Kaori Yoshida

Learn More
Many-objective optimization refers to optimization problems with a number of objectives considerably larger than two or three. In this paper, a study on the performance of the Fast Elitist Non-dominated Sorting Genetic Algorithm (NSGA-II) for handling such many-objective optimization problems is presented. In its basic form, the algorithm is not well suited(More)
Over the years, studies have focused on the transcriptional regulation of oncogenesis. More recently, a growing emphasis has been placed on translational control. The Ras and Akt signal transduction pathways play a critical role in regulating mRNA translation and cellular transformation. The question arises: How might the Ras and Akt signaling pathways(More)
The poly(A)-binding protein (PABP) is a unique translation initiation factor in that it binds to the mRNA 3' poly(A) tail and stimulates recruitment of the ribosome to the mRNA at the 5' end. PABP activity is tightly controlled by the PABP-interacting protein 2 (Paip2), which inhibits translation by displacing PABP from the mRNA. Here, we describe a close(More)
In this paper, a method for the visualization of the population of an evolutionary multi-objective optimization (EMO) algorithm is presented. The main characteristic of this approach is the preservation of Pareto-dominance relations among the individuals as good as possible. It will be shown that in general, a Pareto- dominance preserving mapping from(More)
G protein-coupled receptor (GPCR) (also known as seven-transmembrane domain receptor) superfamily represents the largest protein family in the human genome. These receptors respond to various physiological ligands such as photons, odors, pheromones, hormones, ions, and small molecules including amines, amino acids to large peptides and steroids. Thus, GPCRs(More)
Many-objective optimization refers to multi-objective optimization problems with a number of objectives considerably larger than two or three. This papers contributes to the use of Particle Swarm Optimization (PSO) for the handling of such many-objective optimization problems. Multi-objective PSO approaches typically rely on the employment of a so-called(More)
The tumor suppressor kinases LATS1 and LATS2 (LATS1/2) regulate not only organ size through the Hippo signaling pathway, but also cell-cycle checkpoints and apoptosis via other signaling cascades. We previously reported that LATS1/2 localize to the mitotic apparatus, where they are involved in the phosphorylation and activation of the mitotic kinase(More)
A robust method for inducing bone-formation without an autograft has not been established. Currently, both platelet-rich plasma (PRP) and bone morphogenetic protein (BMP) have been widely investigated for their clinical use in such cases. However, their synergistic effect is still controversial and previously shown diversity of this effect depends on(More)
We are studying the NFL Theorems with regard to relational optimization. In relational optimization, we represent the optimization problem by a formal relation, and the solution by the set of maximal (or non-dominated) elements of this relation. This appears to be a natural extension of standard optimization, and covers other notions of optimality as well.(More)