Kaori Otsubo

Learn More
A simple high-performance liquid chromatographic method was developed for the simultaneous determination of the therapeutic levels of acyclovir and ganciclovir in human plasma. After precipitation of plasma proteins with 6% perchloric acid, acyclovir and ganciclovir were simultaneously determined by reversed-phase chromatography with spectophotometric(More)
We report a case of acute myeloid leukemia (AML) with two unrelated clones, one of which was t(11;17)(q23;q25) carrying MLL-SEPT9 fusion transcripts. The patient was a 71-year-old man who was diagnosed with AML M0 and received multiple chemotherapy regimens, including DNA topoisomerase II inhibitors. Although the karyotype of bone marrow cells at the(More)
A capillary electrophoretic method for the simultaneous determination of sulfamethoxazole and trimethoprim in plasma was developed. Sulfamethoxazole and trimethoprim extracted from human plasma with ethyl acetate were analyzed at 20 kV and 25 degrees C using 15 mm phosphate buffer (pH 6.2) as the electrolyte. The detection was by UV at 220 nm. The run time(More)
Background B-cell lymphomas harboring the 8q24/MYC plus 18q21/BCL2 translocations are now referred to as high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-MBR). Although HGBL-MBR is frequently found in cases with diffuse large B-cell lymphoma or Burkitt lymphoma-like B-cell lymphoma, acute lymphoblastic leukemia (ALL)-like(More)
We report a novel three-way translocation involving inversion 16 and chromosome 12 at bands 16p13, 16q22, and 12q24 in a patient with therapy-related acute myeloid leukemia (AML)-M4eo. Conventional G-banding of bone marrow cells at diagnosis was suggestive of inv(16)(p13q22) and a translocation of chromosomes 12 and 16. The presence of inv(16) was confirmed(More)
Acute undifferentiated leukemia (AUL) is a rare subset of acute leukemias, being included in the 2008 edition of the World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissues as a special category called ʻacute leukemias of ambiguous lineageʼ, in which the leukemic cells express no more than one membrane marker of any given(More)
Title: De novo acute lymphoblastic leukemia-like disease of high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: a case report and literature review Authors: Akiko Uchida (a2uchida@marianna-u.ac.jp) Yasushi Isobe (yisobe@marianna-u.ac.jp) Yu Uemura (y2uemura@marianna-u.ac.jp) Yuji Nishio (yuji@marianna-u.ac.jp) Hirotaka Sakai(More)
  • 1