Kaori Ohtomo

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PURPOSE To isolate and characterize cultured myoepithelial cells (MECs) from rat lacrimal gland and determine which purinergic receptor subtypes are present and functional in MECs. METHODS Rat lacrimal glands were subjected to collagenase digestion, and MECs were grown. RT-PCR was performed for the purinergic receptors P2X(7), P2Y(1), P2Y(11), and P2Y(13)(More)
PURPOSE To investigate the effect of tacrolimus on chemokine production by corneal myofibroblasts compared with that of cyclosporine or dexamethasone. METHODS We investigated the expression of FK506-binding protein 12, calcineurin, and nuclear factor of activated T cells in corneal myofibroblasts by immunocytochemistry and flow cytometry. Next, we(More)
UNLABELLED Background: Conjunctival intraepithelial neoplasia (CIN) is a precursor lesion of conjunctival squamous cell carcinoma (SCC). CIN recurs frequently but progresses less aggressively than SCC. We report 2 cases of recurrent CIN in immunosuppressed patients. CASE 1 A 60-year-old woman had been taking oral immunosuppressive drugs for 30 years for(More)
PURPOSE To investigate the role of the epithelium in severe allergic conjunctivitis. METHODS We first investigated the expression of protease-activated receptors (PARs) in cultured human conjunctival epithelial cells and fibroblasts by reverse transcription-polymerase chain reaction. Next, we examined whether mite allergen-stimulated cells release(More)
To determine the role of TGF-β(1) in the tissue eosinophilia associated with vernal keratoconjunctivitis (VKC), we investigated the immunohistochemical expression of TGF-β(1) and TGF-β(1)-related proteins in giant papillae obtained from VKC patients. We also investigated the effect of TGF-β(1) on production of eotaxin by cultured conjunctival and corneal(More)
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