Kaori Nakamura

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The cyanobacterial circadian oscillator can be reconstituted in vitro by mixing three clock proteins, KaiA, KaiB and KaiC, with ATP. KaiC is the only protein with circadian rhythmic activities. In the present study, we tracked the complex formation of the three Kai proteins over time using blue native (BN) polyacrylamide gel electrophoresis (PAGE), in which(More)
The design of a novel series of cyclin-dependent kinase (CDK) inhibitors containing a macrocyclic quinoxaline-2-one is reported. Structure-based drug design and optimization from the starting point of diarylurea 2, which we previously reported as a moderate CDK1,2,4,6 inhibitor [J. Biol.Chem.2001, 276, 27548], led to the discovery of potent CDK1,2,4,6(More)
A premature male infant weighing 1,508 g had appendicitis with perforation. Surgical intervention was decided on 9 days after birth because of abdominal signs, an erythematous rash, and the appearance of the abdominal radiograph. Disseminated intravascular coagulation was relieved by an exchange transfusion. Total parenteral nutrition was started 4 days(More)
The courses and terminal patterns of the fasciculus retroflexus (FR) in the interpeduncular nucleus (IP) were studied in the mouse, using the rapid Golgi method. Mainly on the basis of the distribution areas and terminal patterns, the FR fibers are divided into two types. The type 1 FR fibers are coarse in contour and take zigzag courses to distribute(More)
It has been revealed recently that molecular crowding, which is one of the largest differences between in vivo and in vitro conditions, is a critical factor determining the structure, stability, and function of nucleic acids. However, the effects of molecular crowding on Watson-Crick and Hoogsteen base pairs remain unclear. In order to investigate directly(More)
Glycosphingolipids (GSLs) are essential membrane components of eukaryotic cells. Recently, a new type of fungal neogala-series GSL was identified in aureobasidin A-resistant fungi. In this study, we analyzed GSLs from four pathogenic fungal strains belonging to the order Hypocreales, and found that Mariannaea elegans contained both acidic GSLs and neutral(More)
In medical diagnostic imaging, an X-ray CT scanner or a MRI system have been widely used to examine 3D shapes or internal structures of living organisms or bones. However, these apparatuses are generally very expensive and of large size. A prior arrangement is also required before an examination, and thus, it is not suitable for an urgent fracture diagnosis(More)
Objective: To investigate skin, subepidermal low echogenic band (SELEB), and subcutaneous tissue (SCT) thickness as well as the degree of increase in subcutaneous echogenicity (SEG) and subcutaneous echo-free space (SEFS) in arms with lymphedema (LE). Materials and Methods: The skin and SCT of both arms of 30 patients with unilateral stage II breast(More)
A 69-year-old Japanese woman with erythema, severe edema on the face, Gottron's papules and poikiloderma was diagnosed as having dermatomyositis. She also noticed muscle weakness in her extremities, although her electromyogram showed neurogenic patterns. Her levels of CA19-9 and CEA were elevated and a CT of her abdomen revealed a giant, multilobular,(More)
A surface plasmon resonance (SPR) sodium ion sensor using an ion optode membrane film was experimentally and theoretically described based on an absorption-based SPR principle proposed in our previous article (Kurihara, K; Suzuki, K. AnaL Chem. 2002, 74, 696-701). The sodium ion concentrations from 10(-6) to 10(-1) have been successfully determined not only(More)