Kannan Elango

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Pro-inflammatory cytokines regulate the magnitude of allergic reactions during asthma. Tumor necrosis factor--alpha (TNF-α), interleukin-6 (IL-6) and interleukin-13 (IL-13) play a crucial role in aggravating the inflammatory conditions during allergic asthma. In addition, oxidative stress contributes to the pathogenesis of asthma by altering the(More)
ETHNOPHARMACOLOGICAL RELEVANCE Calotropis gigantiea (L.) R. Br (Apocynaceae) commonly called as "crown flower" or "giant milk weed" is a well-known weed to many cultures for treating various disorders related to central nervous system, skin diseases, digestive system, respiratory system, reproductive system etc. Indigenous groups made the plant as a part of(More)
BACKGROUND The plants selected for the study were traditionally used in siddha system of medicine in neurological disorders. AIM The aim of the following study isto screen the plant species for both acetylcholinesterase (AchE) and butyrylcholinesterase (BuchE) inhibition by in-vitro Ellman's method and a thin layer chromatography bioautographic assay for(More)
The potential role of the ethanolic extract of Asparagus racemosus (Wild) in the treatment of diabetes along with its antioxidant and antihyperlipidemic effects was studied in streptozotocin induced diabetic rats. Oral administration of ethanolic extract of Asparagus racemosus (EEAR) 200 and 400 mg/kg/b.w for 21 days significantly decreased the blood(More)
The increasing frequency of poorly water soluble new chemical entities exhibiting therapeutic activity is of major concern to the pharmaceutical industry. Olanzapine is an atypical antipsychotic used orally in treatment of Schizophrenia. Also, it has poor aqueous solubility (BCS Class II drug) whose oral bioavailability has been reported as only 40%. In(More)
A simple, sensitive and reproducible method was developed and validated for the simultaneous estimation of diethylcarbamazine and levocetirizine in its tablet formulation by reverse phase high performance liquid chromatography using Waters1515 HPLC with UV detector at the λ(max) of 224 nm, using Princeton Sphere-100 C(18) (250×4.6 mm. 5 μ) column. The(More)
Ethanolic extracts of Ailanthus exceisa (AE). Toddalia asiatica (TA) and Araucaria bidwilli (AB) were screened by the anti-pyretic activity in yeast induced hyperthermic test model in the laboratory. Dose of AE (100), TA (60) and AB (30) mg., equivalent of the plant material per kg. Body weight of the extracts were administered orally to the female albino(More)
The basic nucleus 4-(amino)-5-phenyl-l-4H-1,2,4-triazole-3-thiol was prepared by cyclisation of potassium dithiocarbazinate with hydrazine hydrate using water as solvent under reflux condition for 3-4 h. The compound which has been synthesized successfully was subjected to addition reaction with different aldehydes to synthesize Schiff bases. The compounds(More)
The objective of the present investigation was to develop and evaluate sustained release matrix tablets of prochlorperazine maleate employing different types and levels of hydrophilic matrix agents namely hydroxyl propyl methyl cellulose (HPMC), carbopol and combination of these polymers by wet granulation technique. Prior to compression process, the(More)
The objective of the present investigation was to explore the potential of nanoemulsion (NE) containing artemether-curcumin combination to accomplish the delivery of drugs to the brain via olfactory delivery system for management of cerebral malaria. The components for curcumin NE (C-NE) and artemether NE (A-NE) formulations were selected based on(More)