Kannaboyina Nagaraju

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Dystrophin deficiency causes contraction-induced injury and damage to the muscle fiber, resulting in sustained increase in intracellular calcium levels, activation of calcium-dependent proteases and cell death. It is known that the Ryanodine receptor (RyR1) on the sarcoplasmic reticular (SR) membrane controls calcium release. Dantrolene, an FDA approved(More)
Nasal gliomas are rare congenital mild-line tumors often misdiagnosed as encephalocele, midline dermoid. Nasal gliomas constitute about 5% of congenital midline swellings. Imaging preferably by MRI is mandated to study the extent and to rule out intracranial extension. The gold standard treatment is surgical excision and histo-pathological confirmation. We(More)
A simple, selective, rapid, precise and economical reverse phase high pressure liquid chromatographic method has been developed for the estimation of Pregabalin in pharmaceutical Tablet dosage form. The mobile phase consisted of 50:50 % (v/v) of Methanol & 10mM Ammonium Acetate (pH adjusted to 3.0 with glacial acetic acid) operated on isocratic mode. The(More)
BACKGROUND Duchenne muscular dystrophy (DMD) is an inherited X-linked disorder with an incidence of 1 in 3,500 male births. Early treatment of DMD cardiomyopathy is under investigation and echocardiographic analysis of strain patterns may provide measures to better quantify early treatment outcomes. METHODS We compared cardiac function in 3, 9 and 12(More)
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