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The genomic sequences of Plantago asiatica mosaic virus (PlAMV), six lily isolates and one primrose isolate from Japan, were determined. The genomic size of all isolates was 6102 nucleotides, containing the five open reading frames typical of members of the genus Potexvirus. Pairwise comparison analyses confirmed the close relationship between PlAMV and(More)
The complete nucleotide sequences of RNA1 and RNA2 of a Japanese isolate of Radish mosaic virus (RaMV-J), a crucifer-infecting comovirus, were determined. RNA1 is 6064 nucleotides long and encodes a 210-kDa polyprotein containing conserved motifs that are required for replication. RNA2 is 4020 nucleotides long and encodes a 123-kDa polyprotein containing(More)
Magnaporthe oryzae B. Couch (formerly Magnaporthe grisea (Hebert) Barr) [3] is the causal agent of the devastating rice blast disease [6]. This filamentous fungus is being studied intensively as a principal model organism for understanding plantfungus interactions. Virus-like particles (VLPs) were previously detected in two M. oryzae strains (TH 65-105 and(More)
Follicular lymphoma of the small intestine remains relatively rare, especially in its early stage. Recently, double-balloon endoscopy has enabled observation of the entire small intestine. We describe a case of follicular lymphoma with multiple lesions in the small intestine detected by double-balloon endoscopy. The patient showed multiple whitish granules(More)
Dipeptidyl peptidase-4 (DPP-4) inhibitor is a new class of anti-diabetic drug which exerts its glucose-lowering action by suppressing the degradation of a gut incretin hormone glucagon-like peptide-1 (GLP-1). To elucidate whether treatment with stronger DPP-4 inhibitor on top of angiotensin II type 1 receptor blocker (ARB) provides greater renal protective(More)
A novel class of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) inhibitors was discovered through screening a kinase-focused library. A homology model of MAPKAP-K2 was generated and used to guide the initial SAR studies and to rationalize the observed selectivity over CDK2. An X-ray crystal structure of a compound from the active(More)
From a lily isolate of Plantago asiatica mosaic virus (PlAMV-Li), two sub-isolates (Li1 and Li6) were obtained. Although the nucleotide sequences of Li1 and Li6 were highly conserved, they showed different pathogenicity in Nicotiana benthamiana. Li1 caused necrosis, whereas Li6 infected the plant asymptomatically. Inoculation tests with chimeric and(More)
Delayed enhanced CT was performed in 53 cases and these findings are compared with those of delayed radioisotope scan and with operative and histopathologic findings. We have classified the results of enhancement into four types as follows: (1) immediate enhancement pattern due to rich vascular bed, typical in meningiomas; (2) delayed enhancement pattern(More)
We report a 70-year-old man who presented symptoms resembling those of meningoencephalitis and who was subsequently diagnosed as having a crowned dens syndrome. The patient exhibited severe neck pains, headache, high fever and a pain in his knee joints together with symptoms of the central nervous system. The patient's cerebrospinal fluid was almost clear(More)
Automated nuclei detection and counting from higher dimensional fluorescence images is crucial for many biomedical applications. Common methods either use segmentation followed by centroid extraction or directly extract nuclei centroids. Although direct methods are desirable in order to avoid complex segmentation, most of these methods disregard the(More)