Kanjana Unnwongse

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The symptomatology of auras and seizures is a reflection of activation of specific parts of the brain by the ictal discharge, the location and extent of which represent the symptomatogenic zone. The symptomatogenic zone is presumably, though not necessarily, in close proximity to the epileptogenic zone, the area responsible for seizure generation, the(More)
DYT5 is a condition characterized by levodopa (L-dopa) responsive dystonia (DRD) that shows childhood onset and marked diurnal fluctuation. Patients with DYT5 have heterozygous mutations in the GCH1 gene, which codes for GTP cyclohydrolase I (GTPCH), a rate-limiting enzyme in tetrahydrobiopterin (BH4) synthesis. 1 BH4 is a cofactor for aromatic amino acid(More)
OBJECTIVE This study prospectively examined the relationships among late night salivary cortisol (NSC) levels and depressive symptoms, memory performance, and hippocampal volumes in patients with medically intractable temporal lobe epilepsy (TLE) and the potential mediating effects of cortisol in the relationships between these variables. METHODS(More)
Extraoperative electrical stimulation is frequently used to identify eloquent areas in patients with pharmacoresistant epilepsy who undergo subdural grid evaluation for epilepsy surgery. Oral automatisms elicited by cortical stimulation have been described in the mesial temporal lobe, but also in the mesial frontal lobe, particularly the cingulate gyrus.(More)
About one third of patients with focal epilepsy experience seizures despite adequate medical treatment. In this population, successful epilepsy surgery improves life expectancy and health-related quality of life, while reducing health care costs as a result of reduced hospital admissions, emergency department visits, and use of antiepileptic drugs. The(More)
Symptomatogenic areas for ictal laughter have been described in the frontal and temporal lobes. Within the frontal lobe, gelastic seizures have been recorded from the cingulate gyrus. Electrocortical stimulation of the cingulate gyrus as well as the superior frontal gyrus induced laughter. We describe a patient whose gelastic seizures were associated with(More)
This study investigated the relationship between the apolipoprotein (APOE) ε4 allele and brain volumes in patients with medically intractable temporal lobe epilepsy (TLE). MRI-based volumetric analyses of the hippocampi, cerebral hemispheres, and whole brain were conducted in 59 patients with TLE (31 with left TLE, 28 with right TLE) with hippocampal(More)
Although rare, epilepsy arising from the insula may produce ictal manifestations that can mimic temporal and extratemporal semiologies. If unrecognized, this might lead to some epilepsy surgery failures. Seizures originating in the insula (insular epilepsy) produce semiologies such as sensation of laryngeal/ chest discomfort, contralateral widespread(More)
OBJECTIVE Misleading manifestations of common epilepsy syndromes might account for some epilepsy surgery failures, thus we sought to characterize patients with difficult to diagnose (atypical) mesial temporal lobe epilepsy (mTLE). METHODS We retrospectively reviewed our surgical database over 12 years to identify patients who underwent a standard anterior(More)