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The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes
Constitutive activation of the Wnt pathway/β-catenin signaling may be important in aldosterone-producing adenoma (APA). However, significant gaps remain in our understanding of the prevalence andExpand
Prevalence and clinical correlates of somatic mutation in aldosterone producing adenoma-Taiwanese population
Primary aldosteronism (PA) is a common form of secondary hypertension and has significant cardiovascular consequences. Mutated channelopathy due to the activation of calcium channels has beenExpand
Hemojuvelin modulates iron stress during acute kidney injury: improved by furin inhibitor.
AIMS Free iron plays an important role in the pathogenesis of acute kidney injury (AKI) via the formation of hydroxyl radicals. Systemic iron homeostasis is controlled by theExpand
Hepatocyte growth factor has a role in the amelioration of diabetic vascular complications via autophagic clearance of advanced glycation end products: Dispo85E, an HGF inducer, as a potential
The aim of this study was to evaluate the effect and elucidate the potential mechanism of the extract of rhizomes from Dioscorea alata L. cv. Phyto, Dispo85E, on accelerating the elimination ofExpand
miRNA-203 Modulates Aldosterone Levels and Cell Proliferation by Targeting Wnt5a in Aldosterone-Producing Adenomas
Context The aberrant expression or alternation of miRNA in the pathogenesis of aldosterone-producing adenomas (APAs) is still largely unknown. Objective We investigated the role of miRNA-203Expand
Antiosteoporotic Activity of Dioscorea alata L. cv. Phyto through Driving Mesenchymal Stem Cells Differentiation for Bone Formation
The aim of this study was to evaluate the effect of an ethanol extract of the rhizomes of Dioscorea alata L. cv. Phyto, Dispo85E, on bone formation and to investigate the mechanisms involved. OurExpand
CTNNB1 Mutation in Aldosterone Producing Adenoma
Discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas (APAs) with distinct clinical presentations and pathological features. Catenin β1 (CTNNB1)Expand
Adrenalectomy completely cured hypertension in familial hyperaldosteronism type I patients with somatic KCNJ5 mutation.
CONTEXT Familial hyperaldosteronism type I or glucocorticoid-remediable aldosteronism (FH-I; GRA) is caused by unequal crossing-over of the steroid 11β-hydroxylase (CYP11B1) and aldosterone synthaseExpand
Activation of mitochondrial function and Hb expression in non‐haematopoietic cells by an EPO inducer ameliorates ischaemic diseases in mice
Many organs suffer from ischaemic injuries that reduce their ability to generate sufficient energy, which is required for functional maintenance and repair. Erythropoietin (EPO) ameliorates ischaemicExpand
Presence of Subclinical Hypercortisolism in Clinical Aldosterone-Producing Adenomas Predicts Lower Clinical Success
Supplemental Digital Content is available in the text. The clinical characteristics and outcomes in patients with clinical aldosterone-producing adenomas harboring KCNJ5 mutations with or withoutExpand