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Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma
TLDR
The data suggest that MALAT1 serves as an oncogene in ESCC, and it regulates ESCC growth by modifying the ATM-CHK2 pathway and it seems that the gene amplification in tumor tissues emerges during ESCC progression, but is not derived from germline origins. Expand
Up-regulation of lncRNA CASC9 promotes esophageal squamous cell carcinoma growth by negatively regulating PDCD4 expression through EZH2
TLDR
This study demonstrates that lncRNA CASC9 functions as an oncogene by negatively regulating PDCD4 expression through recruiting EZH2 and subsequently altering H3K27me3 level, and implicates lnc RNA CASC 9 as a valuable biomarker for ESCC diagnosis and prognosis. Expand
CpG island methylation status of miRNAs in esophageal squamous cell carcinoma
TLDR
It is concluded that CpG island methylation of miR‐34a, miR-34b/c andMiR‐129‐2 are frequent events and important mechanism for their low expression in ESCC. Expand
ALDH1A1 defines invasive cancer stem-like cells and predicts poor prognosis in patients with esophageal squamous cell carcinoma
TLDR
The results provide the strong evidence that ALDH1A1high cancer stem-like cells contribute to the invasion, metastasis and poor outcome of human esophageal squamous cell carcinoma. Expand
Polymorphisms of survivin promoter are associated with risk of esophageal squamous cell carcinoma
TLDR
The finding suggested that survivin promoter polymorphisms −625G/C might influence the susceptibility to ESCC in the Chinese population, maybe by influencing survivin expression. Expand
A functional varient in microRNA-146a is associated with risk of esophageal squamous cell carcinoma in Chinese Han
MicroRNAs are a new class of non-proteincoding, small RNAs that function as tumor suppressors or oncogenes. They participate in diverse biological pathways and function as gene regulators. A G>CExpand
Negative regulation of lncRNA GAS5 by miR-196a inhibits esophageal squamous cell carcinoma growth.
TLDR
GAS5 functions as a tumor suppressor gene in ESCC and is regulated by miR-196a involved in RISC, which is a key component of the RNA-induced silencing complex (RISC). Expand
LncRNA CASC9 promotes esophageal squamous cell carcinoma metastasis through upregulating LAMC2 expression by interacting with the CREB-binding protein
TLDR
The research reveals the prognostic and pro-metastatic roles for CASC9 in ESCC, suggesting that CASC 9 could serve as a biomarker for prognosis and a target for metastasis treatment. Expand
Association between Polymorphisms in the Promoter Regions of Matrix Metalloproteinases (MMPs) and Risk of Cancer Metastasis: A Meta-Analysis
TLDR
Investigations demonstrate that polymorphisms in the promoter regions of MMP1, 3, 7 and 9 might be associated with metastasis in some cancers. Expand
miR-16-5p inhibits chordoma cell proliferation, invasion and metastasis by targeting Smad3
TLDR
It is demonstrated that miR-16-5p plays a tumor suppressor role in chordoma progression by targeting Smad3, which could provide a promising prognostic and therapeutic strategy for chordoma treatment. Expand
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