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SK2-containing channels are expressed in the postsynaptic density (PSD) of dendritic spines on mouse hippocampal area CA1 pyramidal neurons and influence synaptic responses, plasticity and learning. The Sk2 gene (also known as Kcnn2) encodes two isoforms that differ only in the length of their N-terminal domains. SK2-long (SK2-L) and SK2-short (SK2-S) are(More)
Many blind motion deblur methods model the motion blur as a spatially invariant convolution process. However, motion blur caused by the camera movement in 3D space during shutter time often leads to spatially varying blurring effect over the image. In this paper, we proposed an efficient two-stage approach to remove spatially-varying motion blurring from a(More)
The Movement Disorder Society Clinical Diagnostic Criteria for Parkinson’s disease (MDS-PD Criteria) was introduced by the Movement Disorder Society in 2015 for research purposes. However, its use for clinical diagnosis of Parkinson disease still needs further revision. This study compares the UK-Criteria versus MDS-PD Criteria in the clinical diagnosis of(More)
Small conductance Ca(2+)-activated K(+) (SK) channels and voltage-gated A-type Kv4 channels shape dendritic excitatory postsynaptic potentials (EPSPs) in hippocampal CA1 pyramidal neurons. Synaptically evoked Ca(2+) influx through N-methyl-D-aspartate receptors (NMDARs) activates spine SK channels, reducing EPSPs and the associated spine head Ca(2+)(More)
Intravitreal injection of corticosteroid has been used to treat diabetic macular edema, however, the exact mechanism remains unknown. In the present experiment, four weeks after streptozotocin administration, intravitreal injection of dexamethasone (50 microg/10 microl) was performed. After 2 d injection, we investigated the effect of dexamethasone on(More)
The filamentous fungus Neurospora crassa is a long-studied eukaryotic microbial system amenable to heterologous expression of native and foreign proteins. However, relatively few highly tunable promoters have been developed for this species. In this study, we compare the tcu-1 and nit-6 promoters for controlled expression of a GFP reporter gene in N.(More)
Most existing nonblind image deblurring methods assume that the blur kernel is free of error. However, it is often unavoidable in practice that the input blur kernel is erroneous to some extent. Sometimes, the error could be severe, e.g., for images degraded by nonuniform motion blurring. When an inaccurate blur kernel is used as the input, significant(More)
Background. Artifacts in clinical intensive care monitoring lead to false alarms and complicate later data analysis. Artifacts must be identified and processed to obtain clear information. In this paper, we present a method for detecting artifacts in PCO2 and PO2 physiological monitoring data from preterm infants. Patients and data. Monitored PO2 and PCO2(More)
BACKGROUND Hepatocellular carcinoma (HCC) is a common malignancy that has a poor prognosis because there is lack of methods for early diagnosis. We aimed to utilize two serum long non-coding RNAs (lncRNAs), uc001ncr and AX800134, to diagnose hepatitis B virus (HBV)-positive HCC. METHODS lncRNA microarrays were utilized to measure the differential(More)
In pyramidal neurons such as hippocampal area CA1 and basolateral amygdala, a slow afterhyperpolarization (sAHP) follows a burst of action potentials, which is a powerful regulator of neuronal excitability. The sAHP amplitude increases with aging and may underlie age related memory decline. The sAHP is due to a Ca(2+)-dependent, voltage-independent K(+)(More)