Kang Il Lee

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The neuron restrictive silencer element (NRSE) has been identified in several neuronal genes and confers neuron specificity by silencing transcription in nonneuronal cells. We have previously reported that Sp1 and an NF-kappaB-like element (NE-1) are required for the promoter activity of mouse dynamin I gene. In the present study, we found that the upstream(More)
The correlates of suicide rates were determined by conducting a multivariate study of sociodemographic indicators and suicide rates of 261 Canadian census divisions. Twenty-one sociodemographic variables were entered into a stepwise multiple linear regression to develop a model for suicide rates. The important variables were mortality rate for all causes of(More)
Electrohydraulic shift control of a vehicle automatic transmission has been predominantly carried out via open-loop control based on numerous time-consuming calibrations. Despite remarkable success in practice, the variations of system characteristics inevitably cause the performance of the tuned open-loop controller to deteriorate. As a result, the(More)
Regarding the molecular mechanism of dynamin in receptor-mediated endocytosis, GTPase activity of dynamin has been thought to have a critical role in endocytic vesicle internalization. However, a recent report suggested that GTP-binding to dynamin itself activates the dynamin to recruit molecular machinery necessary for endocytosis. In this study, to(More)
Conessine, a steroidal alkaloid isolated from Holarrhena floribunda, has anti-malarial activity and interacts with the histamine H3 receptor. However, the cellular effects of conessine are poorly understood. Accordingly, we evaluated the involvement of conessine in the regulation of autophagy. We searched natural compounds that modulate autophagy, and(More)
Reserpine is a well-known medicine for the treatment of hypertension and schizophrenia, but its administration can induce Parkinson's disease (PD)-like symptoms in humans and animals. Reserpine inhibits the vesicular transporter of monoamines and depletes the brain of monoamines such as dopamine. However, the cellular function of reserpine is not fully(More)
The PKA-CREB signaling pathway is involved in many cellular processes including autophagy. Recent studies demonstrated that PKA-CREB inhibits autophagy in yeast; however, the role of PKA-CREB signaling in mammalian cell autophagy has not been fully characterized. Here, we report that the integral membrane protein ITM2A expression is positively regulated by(More)
Speed of sound (SOS) was measured in 14 bovine femoral trabecular bone samples with and without the cortical endplates with various thicknesses of 1.00, 1.31, 1.47, 1.75, and 2.00 mm. The presence of the cortical endplates resulted in an increase in the mean SOS of 16 m/s (+0.9%) to 91 m/s (+5.3%). The mean SOS measured in the samples with and without the(More)
The present study aims to identify a new recipe for reusable tissue mimicking phantoms that allows the optical visualization of thermal lesions produced in various applications of therapeutic ultrasound where thermal mechanisms are important. The phantom was made of polyacrylamide hydrogel containing a nonionic surface-active agent (NiSAA) as a(More)
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