Kanako Nakajima

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Myasthenia gravis (MG) is an autoimmune disorder generally mediated by antibodies against the acetylcholine receptors (AChR) of the skeletal muscles. CD4 T cells help B cells to produce antibodies through their production of cytokines or chemokines. In this study, we evaluated the frequency of regulatory (Treg) and IL-17 producing CD4 T-cell subsets (Th17)(More)
Myasthenia gravis (MG) is an autoimmune neuromuscular disorder with a chronic clinical course that requires long-term glucocorticoid (GC) therapy. A drug efflux pump, P-glycoprotein (P-gp), actively transports GC out of target cells, thereby reducing its efficacy. We evaluated the P-gp function of peripheral-blood mononuclear cells in 59 MG patients. P-gp(More)
Myasthenia gravis is an autoimmune disorder mediated by antibodies against the acetylcholine receptors of the skeletal muscles. Imbalances between T helper type 1 and type 2 cytokine production play a key role in the induction and development of several autoimmune diseases. Peripheral T helper type 1 and type 2 cells in 50 myasthenia gravis patients were(More)
Myasthenia gravis (MG) is an autoimmune disorder generally mediated by antibodies against the acetylcholine receptors of the skeletal muscles. Depending on the disease burden, MG patients may experience chronic dysregulation of both the hormonal stress axis and the immune system, consequently, aggravating the disease itself but also leading to secondary(More)
BACKGROUND Hip fracture in the elderly is a serious problem, and solutions to prevent falls are needed. OBJECTIVE This study focused on elucidating data critical to fall prevention by evaluating ambulatory function, and we achieved this by developing a plantar pressure measurement device to determine gait function. METHODS Our device enables measurement(More)
Background: In many human postural studies, the foot is considered to be a rigid body. The human foot is composed of the arch structure, which is characteristic in every person and deforms with aging. Foot arch structure is assumed to effect postural control; however, underlying mechanisms remain unclear. The aim of this study was to elucidate the(More)
This paper proposes a method for automatic extraction of the form of a single neuron from image series which are captured with confocal laser scanning microscopic (CLSM). Deficiency parts appear in binary images through extraction process because of noises in CLSM images. It is needed manual operation to compensate it. Our method connects some discrete(More)
The calcineurin inhibitors, tacrolimus and ciclosporin, are two useful immunosuppressive drugs for the treatment of myasthenia gravis (MG), for patients who have low responses to glucocorticoids. We have studied the suppressive potencies of tacrolimus and ciclosporin on concanavalin A-induced blastogenesis of peripheral-blood mononuclear cells (PBMCs)(More)