Kanako Nakajima

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Myasthenia gravis (MG) is an autoimmune disorder generally mediated by antibodies against the acetylcholine receptors (AChR) of the skeletal muscles. CD4 T cells help B cells to produce antibodies through their production of cytokines or chemokines. In this study, we evaluated the frequency of regulatory (Treg) and IL-17 producing CD4 T-cell subsets (Th17)(More)
Myasthenia gravis (MG) is an autoimmune neuromuscular disorder with a chronic clinical course that requires long-term glucocorticoid (GC) therapy. A drug efflux pump, P-glycoprotein (P-gp), actively transports GC out of target cells, thereby reducing its efficacy. We evaluated the P-gp function of peripheral-blood mononuclear cells in 59 MG patients. P-gp(More)
Myasthenia gravis is an autoimmune disorder mediated by antibodies against the acetylcholine receptors of the skeletal muscles. Imbalances between T helper type 1 and type 2 cytokine production play a key role in the induction and development of several autoimmune diseases. Peripheral T helper type 1 and type 2 cells in 50 myasthenia gravis patients were(More)
BACKGROUND Hip fracture in the elderly is a serious problem, and solutions to prevent falls are needed. OBJECTIVE This study focused on elucidating data critical to fall prevention by evaluating ambulatory function, and we achieved this by developing a plantar pressure measurement device to determine gait function. METHODS Our device enables measurement(More)
This paper proposes a method for automatic extraction of the form of a single neuron from image series which are captured with confocal laser scanning microscopic (CLSM). Deficiency parts appear in binary images through extraction process because of noises in CLSM images. It is needed manual operation to compensate it. Our method connects some discrete(More)
Myasthenia gravis (MG) is an autoimmune disorder generally mediated by antibodies against the acetylcholine receptors of the skeletal muscles. Depending on the disease burden, MG patients may experience chronic dysregulation of both the hormonal stress axis and the immune system, consequently, aggravating the disease itself but also leading to secondary(More)
This paper presents a proposal of a method for interpolation of cross-sectional area of a premotor neuron in a silkworm moth brain for form reconstruction of the neuron. We have proposed a method for the automatic interpolation of partial deficiencies which occur in extraction processes of the form of a neuron because of noise in CLSM images. However,(More)