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Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion.

GPR120 is expressed abundantly in K cells of the upper small intestine and plays a critical role in lipid-induced GIP secretion.
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Fatty acid-binding protein 5 regulates diet-induced obesity via GIP secretion from enteroendocrine K cells in response to fat ingestion.

It is demonstrated that bile efficiently amplifies fat-induced GIP secretion and that FABP5 contributes to the development of DIO in a GIP-dependent manner.
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Inhibition of Gastric Inhibitory Polypeptide Receptor Signaling in Adipose Tissue Reduces Insulin Resistance and Hepatic Steatosis in High-Fat Diet–Fed Mice

Interestingly, insulin resistance, liver weight, and hepatic steatosis were reduced in HFD-fed GIPRadipo−/− mice, and suppression of cytokine signaling 3 (SOCS3) signaling was reduced, which may involve IL-6 signaling.
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Long-Chain Free Fatty Acid Receptor GPR120 Mediates Oil-Induced GIP Secretion Through CCK in Male Mice

Results indicate that corn oil-induced GIP secretion from K cells involves both GPR120 and GPR40 signaling pathways, and G PR120-inducedGIP secretion is indirectly mediated by CCK.
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Distribution and hormonal characterization of primary murine L cells throughout the gastrointestinal tract

Characteristics of L cells of the upper small intestine, the lower small intestine and the colon are identified using glucagon‐green fluorescent protein‐expressing mice that express GFP driven by the proglucagon promoter.
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Transcriptional factor Pdx1 is involved in age-related GIP hypersecretion in mice.

It was found that K-cell number and GIP and pancreatic and duodenal homeobox-1 (Pdx1) expression in K cells were increased in aged mice, which showed greater GIP secretion compared with young mice, and posteriori suppression of Pdx1 in small intestine resulted in decreased K- cell number, GIP expression, and Gip secretion in the P dx1-knockdown intestine.
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Free fatty acid receptors, G protein‐coupled receptor 120 and G protein‐coupled receptor 40, are essential for oil‐induced gastric inhibitory polypeptide secretion

This study investigated the effect of the two receptors on oil‐induced GIP secretion using GPR120‐ and GPR40‐double knockout (DKO) mice.
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Vital capacity induction with 8% sevoflurane and N2O causes cerebral hyperemia

Vital capacity inhalation of 8% sevoflurane produces a faster loss of eyelash reflex than does 5% se VfLurane or propofol, but increases cerebral blood volume.
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Electroconvulsive therapy with thiamylal or propofol during pregnancy

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2343-PUB: Reduction of HbA1c after SGLT2 Inhibitors Correlate with Change in Plasma Osmolarity but Not with Elevation of Hematocrit in Japanese Patients with Type 2 Diabetes

It is suggested that the elevation of hematocrit and decrease in HbA1c after the administration of SGLT2 inhibitors have different relation with parameters reflecting diuretic effects.
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