Kamlesh Kumar Sahu

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Dimer formation is likely the first step in the oligomerization of α-synuclein in Lewy bodies. In order to prevent α-synuclein aggregation, knowledge of the atomistic structures of possible α-synuclein dimers and the interaction affinity between the dimer domains is a necessary prerequisite in the process of rational design of dimerization inhibitors. Using(More)
BACKGROUND It is a well-known fact that there is a huge gap between mental health service availability and needs of people in the community. Community Mental Health Program (CMHP) appears as a solution for it. Paripurnata (a non-governmental organization) has been running a CMHP at Habra, West Bengal, India since 2000. Since 2005 a psychiatric out-patient(More)
In this study we have undertaken the theoretical analysis of the effect of R249S carcinogenic and H168R-R249S suppressor mutation at core domain of the tumor suppressor protein p53, on its natural interaction with DNA using a newly developed method. The results show that the carcinogenic mutation R249S affects the flexibility of L3 loop region in p53,(More)
The mutation of Arginine273 to Histidine in the DNA binding domain of p53 is one of the most common mutations found in human cancer. Though R273H mutation retains wild-type conformation, the sequence-specific DNA binding is impaired and subsequently lack of trans-activation function and the ability to suppress cell growth. CP-31398 can restore DNA binding(More)
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