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- Simon D. Bamforth, José Francisco Manta Bragança, +7 authors Shoumo Bhattacharya
- Nature Genetics
- 2001
The protein EP300 and its paralog CREBBP (CREB-binding protein) are ubiquitously expressed transcriptional co-activators and histone acetyl transferases. The gene EP300 is essential for normal… (More)
- Monika Mortensen, Elizabeth J. Soilleux, +9 authors Anna Katharina Simon
- The Journal of experimental medicine
- 2011
The role of autophagy, a lysosomal degradation pathway which prevents cellular damage, in the maintenance of adult mouse hematopoietic stem cells (HSCs) remains unknown. Although normal HSCs sustain… (More)
- Kamil R Kranc, Simon D. Bamforth, José Bragança, Chris J. Norbury, Maarten van Lohuizen, Shoumo Bhattacharya
- Molecular and cellular biology
- 2003
Cited2 (CBP/p300 interacting transactivator with ED-rich tail 2) is required for embryonic development, coactivation of transcription factor AP-2, and inhibition of hypoxia-inducible factor 1… (More)
- Jon Waarst Gregersen, Kamil R Kranc, +6 authors Lars Fugger
- Nature
- 2006
Genes in the major histocompatibility complex (MHC) encode proteins important in activating antigen-specific immune responses. Alleles at adjacent MHC loci are often in strong linkage disequilibrium;… (More)
- Kamil R Kranc, Hein Schepers, +8 authors Tariq Enver
- Cell stem cell
- 2009
The regulatory pathways necessary for the maintenance of adult hematopoietic stem cells (HSCs) remain poorly defined. By using loss-of-function approaches, we report a selective and cell-autonomous… (More)
- Kamil R Kranc, Gail J. Pyne, +6 authors J. F. Clark
- European journal of biochemistry
- 2000
Subarachnoid haemorrhage is often followed by haemolysis and concomitant oxidative stress, and is frequently complicated by pathological vasoconstriction or cerebral vasospasm. It is known that… (More)
- Maria Harkiolaki, Samantha L. Holmes, +16 authors Lars Fugger
- Immunity
- 2009
Environmental factors account for 75% of the risk of developing multiple sclerosis (MS). Numerous infections have been suspected as environmental disease triggers, but none of them has consistently… (More)
- Monika Mortensen, Elizabeth J. Soilleux, +9 authors Anna Katharina Simon
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenanceThe autophagy protein Atg7 is essential for hematopoietic stem cell maintenance' This article is distributed under the… (More)
- Kamil R Kranc, Daniel V. Oliveira, +10 authors José Bragança
- Stem cells
- 2015
Identifying novel players of the pluripotency gene regulatory network centered on Oct4, Sox2, and Nanog as well as delineating the interactions within the complex network is key to understanding… (More)
- Simon D. J. Calaminus, Amelie V Guitart, +5 authors Laura M Machesky
- PloS one
- 2012
The development of a megakaryocyte lineage specific Cre deleter, using the Pf4 (CXCL4) promoter (Pf4-Cre), was a significant step forward in the specific analysis of platelet and megakaryocyte cell… (More)