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The cancer glycocalyx mechanically primes integrin-mediated growth and survival

• Matthew J. Paszek, Christopher C Dufort, +17 authors Valerie M. Weaver
• Nature
• 2014

Malignancy is associated with altered expression of glycans and glycoproteins that contribute to the cellular glycocalyx. We constructed a glycoprotein expression signature, which revealed that… (More)

Density Variant Glycan Microarray for Evaluating Cross-Linking of Mucin-like Glycoconjugates by Lectins

• Kamil Godula, Carolyn R Bertozzi
• Journal of the American Chemical Society
• 2012

Interactions of mucin glycoproteins with cognate receptors are dictated by the structures and spatial organization of glycans that decorate the mucin polypeptide backbone. The glycan-binding… (More)

Glycocalyx Remodeling with Proteoglycan Mimetics Promotes Neural Specification in Embryonic Stem Cells

• Mia L. Huang, Raymond A. A. Smith, Greg W. Trieger, Kamil Godula
• Journal of the American Chemical Society
• 2014

Growth factor (GF) signaling is a key determinant of stem cell fate. Interactions of GFs with their receptors are often mediated by heparan sulfate proteoglycans (HSPGs). Here, we report a cell… (More)

Modulation of Ocular Surface Glycocalyx Barrier Function by a Galectin-3 N-terminal Deletion Mutant and Membrane-Anchored Synthetic Glycopolymers

• Jerome Mauris, Flavio Mantelli, +5 authors Pablo Argüeso
• PloS one
• 2013

BACKGROUND Interaction of transmembrane mucins with the multivalent carbohydrate-binding protein galectin-3 is critical to maintaining the integrity of the ocular surface epithelial glycocalyx. This… (More)

Chemoenzymatic Fc Glycosylation via Engineered Aldehyde Tags

• Elizabeth Lane Smith, John P. Giddens, Anthony T. Iavarone, Kamil Godula, Lai-Xi Wang, Carolyn R Bertozzi
• Bioconjugate chemistry
• 2014

Glycoproteins with chemically defined glycosylation sites and structures are important biopharmaceutical targets and critical tools for glycobiology. One approach toward constructing such molecules… (More)

Synthesis of Glycopolymers for Microarray Applications via Ligation of Reducing Sugars to a Poly(acryloyl hydrazide) Scaffold

• Kamil Godula, Carolyn R Bertozzi
• Journal of the American Chemical Society
• 2010

In this paper, we report on a general synthetic strategy for the assembly of glycopolymers that capitalizes on the intrinsic reactivity of reducing glycans toward hydrazides to form stable cyclic… (More)

Control of the Molecular Orientation of Membrane-Anchored Biomimetic Glycopolymers

• Kamil Godula, Marissa L. Umbel, David Rabuka, Zsofia Botyanszki, Carolyn R Bertozzi, Raghuveer Parthasarathy
• Journal of the American Chemical Society
• 2009

Quantifying and controlling the orientation of surface-bound macromolecules is crucial to a wide range of processes in areas as diverse as biology, materials science, and nanotechnology. Methods… (More)

Efficient synthesis of heparinoid bioconjugates for tailoring FGF2 activity at the stem cell-matrix interface.

• Greg W. Trieger, Stephen Verespy, Philip L. S. M. Gordts, Kamil Godula
• 2019

Heparan sulfate glycosaminoglycans (HS GAGs) attached to proteoglycans harbor high affinity binding sites for various growth factors (GFs) and direct their organization and activity across the… (More)

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