Kameron Leigh Matthews

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Mammalian dentitions are highly patterned, with different types of teeth positioned in different regions of the jaws. BMP4 is an early oral epithelial protein signal that directs odontogenic gene expression in mesenchyme cells of the developing mandibular arch. BMP4 was shown to inhibit expression of the homeobox gene Barx-1 and to restrict expression to(More)
PURPOSE To investigate the cellular origin of nitric oxide released from the rabbit retina in response to physiological stimulation with light. METHODS The release of nitric oxide from the retina was measured in rabbits anesthetized with urethane. An eye-cup was prepared and was filled with Krebs-Ringer bicarbonate. After washing for 45 minutes, 0.5 ml(More)
PURPOSE To investigate whether the inhibitory effect of nitric oxide (NO) on dopamine release from the retina is due to chemical oxidation of dopamine in the extracellular medium rather than to an inhibitory effect on dopamine release from retinal neurons. METHODS Dopamine was incubated in Krebs bicarbonate medium and its rate of chemical degradation(More)
There is an urgent clinical need for a safe, efficacious stimulant of gastric emptying; current therapies include erythromycin (an antibiotic with additional properties which preclude chronic use) and metoclopramide (a 5-hydroxytryptamine type 4 receptor agonist and an antagonist at brain D2 receptors, associated with movement disorders). To move away from(More)
PURPOSE To investigate a possible interaction between cholinergic and nitrergic amacrine cells in the rabbit retina. METHODS The activity of cholinergic amacrine cells was estimated by measuring the light-evoked release of [3H]-acetylcholine (ACh) from the retina of rabbits anesthetized with urethane. An eyecup was prepared and filled with Krebs-Ringer(More)
The retina possesses subpopulations of amacrine cells, which utilize different transmitters, including acetylcholine (ACh), GABA, and dopamine. We have examined interactions between these neurones by studying the effects of nicotinic agonists on GABA and dopamine release. Isolated rabbit retinas were incubated with [3H]dopamine and then superfused.(More)
Parallel groups for children, adolescents, and parents have been a usual modality in the Community Guidance Center for over 12 years. This has provided effective therapeutic intervention. However, an inherent difficulty in these groups was discussion with parents about the identified patient's progress. Various methods, on a trial-and-error basis, were(More)
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