Kamal Hirbli

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Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000(More)
BACKGROUND The burden of diabetes in Lebanon requires well-targeted interventions for screening type 2 diabetes mellitus (T2DM) and prediabetes and prevention of risk factors. Newly recruited 998 Lebanese individuals, in addition to 7,292 already available, were studied to investigate the prevalence of diabetes, prediabetes and their associated risk(More)
pyruvate metabolism. The cardiac concentration of pyruvate, a molecule with a cardioprotective action, is the result of the equilibrium between production and utilization. Pyruvate may be metabolized to acetyl CoA and utilized for oxidation in the Krebs cycle or used for fatty acid (FA) synthesis if the level of ATP is high. It may also be transformed into(More)
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