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1. The effects of the volatile oil (V.O.) of the black seed (Nigella sativa) on the arterial blood pressure and heart of urethane-anaesthetized rats were investigated and the effects were compared with those of its constituent thymoquinone (T.Q.). 2. Intravenous administration of V.O. in the dose range (4-32 microliters kg.-1) or T.Q. (0.2-1.6 mg kg-1) to(More)
1. The effect of the volatile oil (VO) of the black seed (Nigella sativa) on the respiratory system of the urethane-anaesthetized guinea-pig was investigated and compared with those of its constituent thymoquinone (TQ). 2. Intravenous administration of VO in the dose range (4-32 microliters kg-1) induced dose-dependent increases in the respiratory rate and(More)
Prostacyclin, an unstable metabolite of arachidonic acid metabolism, has been shown to have potent platelet antiaggregatory and vasodilator activity. Available evidence suggests that arterial prostacyclin production is diminished in the diabetic state. In this study we have examined the sensitivity of platelets from diabetic subjects to the antiaggregatory(More)
1. The influence of the antifilarial drug diethylcarbamazine citrate (D) and DL-erythro mefloquine hydrochloride (Mf) on PGI2 synthesis by the male rat thoracic aorta and day-20 pregnant rat myometrium was investigated in vitro using a rat platelet antiaggregatory bioassay method. 2. Pretreatment of the tissues with D (25.5-204 microM) or Mf (24-192 microM)(More)
The activity of N-alkyl-1,2-diphenylethanolamines against CaCl2-induced cardiac arrhythmia was evaluated in the rat. The potencies of the compounds were compared with that of the established calcium ion-channel blocker, verapamil. The N-methyl, N-ethyl, and N-isobutyl derivatives as well as verapamil at doses of 2-8 mumols kg-1 protected the animals against(More)
The present study reports Gas chromatographic mass analysis (GC-MS) as well as important biological activities of Cymbopogon proximus essential oil. The chemical composition of the essential oil of Cymbopogon proximus was investigated by GC-MS. Furthermore, the effects of Cymbopogon proximus essential oil on the cardiac parasympathetic ganglia in rats, the(More)
Prostacyclin (PGI2) the major product of arachidonic acid metabolism in blood vessels has potent platelet anti-aggregatory and vasodilator activities. Recently it has been shown that PGI2 production is depressed in arterial tissue from diabetic patients. We have studied the effect of experimental diabetes on PGI2 production in both arterial and myometrial(More)
The influence of sesame and cod liver oils (0.5 and 1 g/kg/day s.c. for 2 weeks) on arterial PGI2 synthesis in the rat was investigated using a rat platelet antiaggregatory bioassay and HPLC methods. Smaller doses did not affect PGI2 synthesis. However, sesame oil at a dose of 1 g/kg/day significantly stimulated PGI2 synthesis, whereas cod liver oil at the(More)
1. The effects of niridazole and chloroquine on rat arterial and myometrial prostacyclin (PGI2) synthesis in vitro were investigated by use of a rat platelet antiaggregatory bioassay. Niridazole (233 microM) and chloroquine (97 microM) inhibited PGI2 synthesis in both tissues. 2. Niridazole-induced inhibition in the myometrium was not reversed by exogenous(More)
Porcine relaxin (30 microgram/ml) when incubated with separated myometrial tissue from 20 day pregnant rats inhibited basal prostacyclin output by 50%. However, relaxin did not inhibit the increased prostacyclin output observed when myometrial tissue was incubated with the prostaglandin precursor, arachidonic acid (10 microgram/ml). When prostacyclin(More)