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- Joseph A. Ball, Kalle M. Mikkola, Amol Sasane
- SIAM J. Control and Optimization
- 2005

We obtain state-space formulas for the solution of the Nehari-Takagi/sub-optimal Hankel norm approximation problem for infinite-dimensional systems with a nonexponentially stable generator, via the method of J-spectral factorization. We make key use of a purely frequency domain solution of the problem. Acknowledgements: This work was completed during a stay… (More)

- D S Kanter, K M Mikkola, S R Patel, J A Parker, S Z Goldhaber
- Chest
- 1997

STUDY OBJECTIVES
To determine the risk factors and frequency of intracranial hemorrhage among patients undergoing thrombolysis for pulmonary embolism.
DESIGN
A retrospective descriptive and controlled analysis.
SETTING
Hospitalized patients at centers in the United States, Canada, and Italy.
PATIENTS
All had evidence of pulmonary embolism on perfusion… (More)

- K M Mikkola, S R Patel, J A Parker, F Grodstein, S Z Goldhaber
- American heart journal
- 1997

The efficacy and safety of thrombolysis in patients with cancer with pulmonary embolism is uncertain. Therefore we studied the effects of thrombolysis in 57 patients with cancer and 254 patients without cancer who were treated in five clinical trials with tissue plasminogen activator or urokinase for pulmonary embolism. Immediately after thrombolysis, the… (More)

- K M Mikkola, S R Patel, J A Parker, F Grodstein, S Z Goldhaber
- American heart journal
- 1997

We reviewed our database of 312 patients with pulmonary embolism who received thrombolysis in five clinical trials. At baseline, none had a history of stroke, internal bleeding within 6 months, surgery within 10 days, or occult blood in stool. Sixty-six major bleeding episodes occurred within 72 hours of administering thrombolysis in 61 (20%) patients:… (More)

- Kalle M. Mikkola
- MCSS
- 2008

- Kalle M. Mikkola
- SIAM J. Control and Optimization
- 2007

It is known that a matrix-valued transfer function P has a stabilizing dynamic controller Q (i.e., h I −Q −P I i −1 ∈ H ∞) iff P has a right (or left) coprime factorization. We show that the same result is true in the operator-valued case. Thus, the standard Youla–Bongiorno parameteriza-tion applies to every dynamically stabilizable function. We then derive… (More)

- Kalle M. Mikkola
- IMA J. Math. Control & Information
- 2008

- Kalle M. Mikkola, TEKNILLINEN KORKEAKOULU, TEKNISKA HÖGSKOLAN
- 2007

We show that every operator that acts between two nonseparable Hilbert spaces can be “block diagonalized”, where each diagonal block acts between two separable Hilbert spaces. Analogous results hold for operatorvalued H∞, Lstrong, H strong and Lpstrong functions and others. Using these results, several theorems about representation, interpolation,… (More)

- D R Hirsch, K M Mikkola, +4 authors S Z Goldhaber
- American heart journal
- 1996

Activated protein C resistance caused by factor V Leiden mutation is the most common inherited cause of an underlying predisposition to pulmonary embolism (PE) and deep venous thrombosis (DVT). We studied the frequency of the factor V Leiden mutation in 50 women who had PE and/or DVT during or after pregnancy or during oral contraceptive use. Ten (20%; 95%… (More)

- Kalle M. Mikkola
- 1998

We formulate a minimax game which is equivalent to the Nehari problem in the sense that this minimax game is well-posed if and only if the Hankel norm of a given operator is less than a prescribed constant. This game and the dual game provide us with physical interpretations of the Riccati operators that are commonly used in the solution of the Nehari… (More)