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Dorsal root ganglion (DRG) neurons, in 22 degrees C tissue culture containing nerve growth factor, taken from normal and trisomy 21 human fetal tissues, were subjected to current and voltage clamp measurements using a tight-seal whole-cell recording technique. Measurements were made between 1 and 2 weeks in culture, when the electrical properties of both… (More)
The effect of the selective oestrogen receptor modulator, toremifene, to inhibit ovariectomy-induced bone loss was studied in rats. The oral doses were 0.3, 3.0 or 30 mg/kg/day for 2 months. 17beta-oestradiol (5 microg/kg/day, subcutaneously) was used as positive control. One group was also treated with a combination of 17beta-oestradiol (5 microg/kg) and… (More)
OBJECTIVES This study was carried out to evaluate the damage induced in red blood cells by exposure to impulse vibration. METHODS The peak accelerations of impulse vibration included 50, 100, 200, 250 and 300 x 10(3) km/s2. A blood sample was put in a container filled with heparin so that there was no space inside. For each peak acceleration the exposure… (More)
High temperature alkaline chemical liquids have caused injuries and hazardous situations in Finnish pulp manufacturing mills. There are no requirements and/or test method standards concerning protection against high temperature alkaline chemical splashes. This paper describes the test method development process to test and identify materials appropriate for… (More)
The effect of ethanol on the electrical membrane properties of cultured human fetal sensory neurons was studied with the whole cell tight seal technique. Alcohol diminished in high concentrations (greater than 200 mM) Na- and K-conductance.