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We generated mouse mutants with targeted AMPA receptor (AMPAR) GluR-B subunit alleles, functionally expressed at different levels and deficient in Q/R-site editing. All mutant lines had increased AMPAR calcium permeabilities in pyramidal neurons, and one showed elevated macroscopic conductances of these channels. The AMPAR-mediated calcium influx induced(More)
The paper evaluates empirically the suit-ability of Stochastic Local Search algorithms (SLS) for nding most probable explanations in Bayesian networks. SLS algorithms (e.g., GSAT, WSAT [16]) have recently proven to be highly eective in solving complex constraint-satisfaction and sat-isability problems which cannot be solved by traditional search s c hemes.(More)
Retrospective pharmacogenetic analysis was performed on 120 Caucasian subjects. Subjects were obtained in collaboration with the Estonian Genome Project and Egeen Inc. (CA, USA), who provided blinded medical record and genetic data to the researchers, respectively. Subjects selected from the Estonian Genome Project had a diagnosis of hypertension confirmed(More)
In this study, a large number of receptor mutants were generated and several N-terminally modified galanin analogues synthesized to refine the previously proposed binding site model for galanin to its GTP-binding-protein-coupled receptor GalR1. In addition to ligand-binding studies, the functionality of mutant receptors was evaluated by assessing their(More)
The paper presents and evaluates the power of a new scheme that generates search heuristics mechanically for problems expressed using a set of functions or relations over a finite set of variables. The heuristics are extracted from a parameterized approximation scheme called Mini-Bucket elimination that allows controlled trade-off between computation and(More)
Many receptor mutants were generated and several NH2-terminally modified galanin analogs synthesized to define the regions of hGalR1 involved in galanin binding. Ligand binding properties and functionality of mutant receptors were evaluated. The His264Ala and Phe282Ala receptor mutants, although deficient in binding in the concentration range of galanin(More)
The chimeric peptide M35 [galanin(1-13)-bradykinin(2-9) amide] is a high-affinity galanin receptor ligand acting as a galanin receptor antagonist in the rat spinal cord, rat hippocampus and isolated mouse pancreatic islets. We have radiolabelled M35 and performed equilibrium binding studies with [125I]M35 on the rat pancreatic beta-cell line Rin m 5F,(More)
This paper evaluates the power of a new scheme that generates search heuristics mechanically. This approach w as presented and evaluated rst in the context of optimization in belief networks. In this paper we extend this work to Max-CSP. The approach i n volves extracting heuristics from a parameterized approximation scheme called Mini-Bucket elimination(More)
Computing lower bounds to the best-cost extension of a tu-ple is an ubiquous task in constraint optimization. A particular case of special interest is the computation of lower bounds to all singleton tu-ples, since it permits domain pruning in Branch and Bound algorithms. In this paper we introduce MCTE(z), a general algorithm which allows the computation(More)