• Publications
  • Influence
The Simcyp population-based ADME simulator.
The Simcyp population-based absorption, distribution, metabolism and excretion simulator is a platform and database for 'bottom-up' mechanistic modelling and simulation of the processes of oralExpand
  • 263
  • 22
The Simcyp® Population-based ADME Simulator
The Simcyp® population-based absorption, distribution, metabolism and excretion simulator is a platform and database for ‘bottom-up’ mechanistic modelling and simulation of the processes of oralExpand
  • 308
  • 9
Parameter optimisation in iterative learning control
  • Kairui Feng
  • Mathematics, Computer Science
  • European Control Conference (ECC)
  • 1 September 2003
In this paper parameter optimisation through a quadratic performance index is introduced as a method to establish a new iterative learning control law. With this new algorithm, monotonie convergenceExpand
  • 14
  • 4
The Simcyp Population Based Simulator: Architecture, Implementation, and Quality Assurance
Developing a user-friendly platform that can handle a vast number of complex physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) models both for conventional small molecules andExpand
  • 61
  • 2
Multiple classifier integration for the prediction of protein structural classes
Supervised classifiers, such as artificial neural network, partition trees, and support vector machines, are often used for the prediction and analysis of biological data. However, choosing anExpand
  • 38
  • 1
Climate change exacerbates hurricane flood hazards along US Atlantic and Gulf Coasts in spatially varying patterns
One of the most destructive natural hazards, tropical cyclone (TC)–induced coastal flooding, will worsen under climate change. Here we conduct climatology–hydrodynamic modeling to quantify theExpand
  • 13
  • 1
Active and Passive Nearest Neighbor Algorithm: A Newly-Developed Supervised Classifier
K nearest neighbor algorithm (k-NN) is an instance-based lazy classifier that does not need to delineate the entire boundaries between classes. Thus some classification tasks that constantly need aExpand
  • 4
  • 1
Solar and wind energy enhances drought resilience and groundwater sustainability
Water scarcity brings tremendous challenges to achieving sustainable development of water resources, food, and energy security, as these sectors are often in competition, especially during drought.Expand
  • 3
  • 1
Assessing hurricane damage costs in the presence of vulnerability model uncertainty
Probability-based assessment of hurricane damage costs for coastal communities is vital for policy-makers and insurers. The uncertainties associated with hurricane damage costs include both theExpand
  • 9
  • 1
A reconstruction of Florida Traffic Flow During Hurricane Irma (2017)
Recent Hurricane Irma (2017) created the most extensive scale of evacuation in Florida's history, involving about 6.5 million people on mandatory evacuation order and 4 million evacuation vehicles.Expand
  • 1
  • 1