Kailun Zhang

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Maraviroc (MVC), a specific antagonist of CCR5 expressed on macrophages and activated T cells, may modulate inflammation and may be useful in patients with HIV infection. In this study we used nonhuman primates to examine the effect and mechanism of MVC alone or in combination with cyclosporine (CsA) to prolong cardiac allograft survivals. In an established(More)
The present study used an in vitro model of cold cardioplegia in isolated working rat hearts to evaluate the possible role of ethyl pyruvate (EP) in promoting cardiac function and preventing apoptosis. Two groups of rats were evaluated; the EP (2 mM EP; n=8) and control (n=8) groups. Isolated rat hearts were perfused with Krebs-Henseleit buffer (KHB) for 30(More)
BACKGROUND Inhibition of chemokine receptor 5 (CCR5), a chemokine receptor expressed on activated T cells, is an effective antiviral therapy in patients with HIV infection, but its efficacy in modulating inflammation and immunity is only just beginning to be investigated. In this study we examined the inhibition of CCR5 in combination with the treatment(More)
OBJECTIVE T helper 17 cells and interleukin-17A have been implicated in the progression of abdominal aortic aneurysm (AAA). Retinoic acid-related orphan receptor gamma thymus, the master transcription factor of T helper 17 cell differentiation, is selectively antagonized by digoxin. However, the effect of antagonizing retinoic acid-related orphan receptor(More)
BACKGROUND Interleukin (IL)-12 and -23 share the p40 subunit and are crucial for the development of T helper (Th) 1- and Th17-cell responses in acute graft rejection. However, little is known about the impact of treatment with antagonistic anti-p40 antibody in inhibiting rejection of cardiac allografts. METHODS C57BL/6 mice were transplanted with(More)
With haptics now common in consumer devices, diversity in tactile perception and aesthetic preferences confound haptic designers. End-user customization out of example sets is an obvious solution, but haptic collections are notoriously difficult to explore. This work addresses the provision of easy and highly navigable access to large, diverse sets of(More)
Candida albicans is a common opportunistic fungal pathogen, causing both superficial candidiasis and life-threatening systemic infections in immune-compromised individuals. Calcium signaling is responsible for this pathogen in responding to several stresses, such as antifungal drugs, alkaline pH and membrane-perturbing agents. Our recent study revealed that(More)
The concept of ephemeral adaptation was introduced to reduce visual search time in GUI menus, while preserving spatial consistency and minimizing distraction. We extend this concept to the visual search of app icons on smartphones, in order to speed up launching apps from a homescreen. We created ephemeral highlighting effects based on preattentive visual(More)
Personal Attributes Extraction in Unstructured Chinese Text Task is a subtask of The 3rd CIPS-SIGHAN Joint Conference on Chinese Language Processing (CLP-2014). In this report, we propose a method based on the combination of trigger words, dictionary and rules to realize the personal attributes extraction. We introduce the extraction process and show the(More)
OBJECTIVE To investigate the role of anti- interleukin-2 receptor (CD25) monoclonal antibody in the regulation of cytokine mRNA expression of IL-1beta, IL-2, CD25, IL-4, IL-5, IL-6, IL-10, tumour necrosis factor-alpha (TNFalpha), and interferon-gamma (IFNgamma) in cardiac allografts to elucidate its immunological mechanism and role in rats that have(More)