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Wind turbine generator system (WTGS) is a complex multi-varies nonlinear system with the characteristics of time - varying, strong coupling and multi - interference. Wind speed is affected by many factors, the magnitude and direction are random. There are numerous of factors such as temperature, weather, environment and so on that affect wind turbine… (More)
A highly diasetereoselective Mannich-type multicomponent reaction was developed to rapidly construct alkynylamide-substituted α,β-diamino acid derivatives from simple starting materials under mild conditions in moderate to good yields for hit hunting. Most of the resulting products 4 exhibited good anticancer activity in HCT116, BEL7402, and SMMC7721 cells.
Protein tyrosine phosphatase 1B (PTP1B) has been proposed to be an effective target for the treatment of both type II diabetes and obesity. However, no PTP1B inhibitor has come into clinic application. Herein, we report mixed 3,3'-bisindoles as novel PTP1B inhibitors with low micromole-ranged inhibitory activity. The best active compound 9f inhibited PTP1B… (More)