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  • Ilwola Mattagajasingh, Cuk-Seong Kim, +6 authors Kaikobad Irani
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2007 (First Publication: 11 September 2007)
  • Reduced caloric intake decreases arterial blood pressure in healthy individuals and improves endothelium-dependent vasodilation in obese and overweight individuals. The SIRT1 protein deacetylaseExpand
  • David J. Sulciner, Kaikobad Irani, Zhao Xiang Yu, Víctor J. Ferrans, P Goldschmidt-Clermont, Toren Finkel
  • Biology, Medicine
  • Molecular and cellular biology
  • 1996 (First Publication: 1 December 1996)
  • The signal transduction pathway leading to the activation of the transcription factor NF-kappaB remains incompletely characterized. We demonstrate that in HeLa cells, transient expression of aExpand
  • Lakshmi Santhanam, Hyun Kyo Lim, +15 authors Dan E. Berkowitz
  • Medicine, Biology
  • Circulation research
  • 2007 (First Publication: 2 August 2007)
  • Endothelial function is impaired in aging because of a decrease in NO bioavailability. This may be, in part, attributable to increased arginase activity, which reciprocally regulates NO synthaseExpand
  • Shailesh S. Deshpande, Piamsook Angkeow, Jf Huang, Mitsunori Ozaki, Kaikobad Irani
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 2000 (First Publication: 1 September 2000)
  • Reactive oxygen species (ROS) have been implicated as mediators of tumor necrosis factor-alpha (TNF) -induced apoptosis. In addition to leading to cell death, ROS can also promote cell growth and/orExpand
  • Mitsunori Ozaki, Shailesh S. Deshpande, +5 authors Kaikobad Irani
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 2000 (First Publication: 1 February 2000)
  • Reperfusion of ischemic tissue results in the generation of reactive oxygen species that contribute to tissue injury. The sources of reactive oxygen species in reperfused tissue are not fullyExpand