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Antitumor evaluation in tumor-bearing mouse is time- and energy-consuming. We aimed to investigate whether in vivo antitumor efficacy could be predicted on the basis of in vitro pharmacodynamics(More)
  • Zhongjian Wang, Hanyu Yang, +9 authors Li Yun Liu
  • Drug metabolism and disposition: the biological…
  • 2019
Atorvastatin is a substrate of cytochrome P450 3a (Cyp3a), organic anion transporting polypeptides (Oatps), breast cancer resistance protein (Bcrp) and P-glycoprotein (P-gp). We aimed to develop a(More)
Generally, diabetes remarkably alters the expression and function of intestinal drug transporters. Nateglinide and bumetanide are substrates of monocarboxylate transporter 6 (MCT6). We investigated(More)
Liver failure altered P-glycoprotein (P-gp) function and expression at blood-brain barrier (BBB), partly owing to hyperammonemia. We aimed to examine the effects of partial portal vein ligation (PVL)(More)