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Combining HLA-DR risk alleles and anti-Epstein-Barr virus antibody profiles to stratify multiple sclerosis risk
Background: Risk factors for multiple sclerosis (MS) include human leukocyte antigen (HLA)-DR and Epstein-Barr virus (EBV)-specific antibody responses, including an epitope within EBV nuclear antigen… Expand
Identifying Patient-Specific Epstein-Barr Nuclear Antigen-1 Genetic Variation and Potential Autoreactive Targets Relevant to Multiple Sclerosis Pathogenesis
Background Epstein-Barr virus (EBV) infection represents a major environmental risk factor for multiple sclerosis (MS), with evidence of selective expansion of Epstein-Barr Nuclear Antigen-1… Expand
The Combined Utility of Ex Vivo IFN-γ Release Enzyme-Linked ImmunoSpot Assay and In Vivo Skin Testing in Patients with Antibiotic-Associated Severe Cutaneous Adverse Reactions.
- J. Trubiano, K. Strautins, +7 authors E. Phillips
- The journal of allergy and clinical immunology…
- 31 October 2017
BACKGROUND For severe cutaneous adverse reactions (SCARs) associated with multiple antibiotics dosed concurrently, clinical causality is challenging and diagnostic approaches are limited, leading to… Expand
Drug-specific upregulation of CD137 on CD8+ T cells aids in the diagnosis of multiple antibiotic toxic epidermal necrolysis.
New genetic predictors for abacavir tolerance in HLA-B*57:01 positive individuals.
Abacavir hypersensitivity syndrome (ABC HSS) is strongly associated with carriage of human leukocyte antigen (HLA)-B*57:01, which has a 100% negative predictive value for the development of ABC HSS.… Expand
Contribution of EBV infection to Multiple Sclerosis Pathogenesis: Human leukocyte antigen restricted, EBV epitope-specific T cell responses in Multiple Sclerosis
Multiple sclerosis (MS) is the most common chronic inflammatory disorder of the central nervous system in young adults and a prototypic autoimmune disease. Similar to other autoimmune diseases the… Expand
7th drug hypersensitivity meeting: part one
Table of contentsOral AbstractsO1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TENDaniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas… Expand
7th Drug hypersensitivity meeting: part two
- Javier Dionicio Elera, Cosmin Boteanu, +434 authors Teodora Lopez Santiago
- Clinical and Translational Allergy
- 25 August 2016
Table of contentsPoster walk 11: miscellaneous drug hypersensitivity 2 (P92–P94, P96–P101)P92 16 years of experience with proton pump inhibitors (PPIs)Javier Dionicio Elera, Cosmin Boteanu, Maria… Expand
P25: THE COMBINED UTILITY OF EX VIVO IFN‐&ggr; RELEASE ENZYME LINKED IMMUNOSPOT AND IN VIVO SKIN TESTING IN PATIENTS WITH ANTIBIOTIC ASSOCIATED SEVERE CUTANEOUS ADVERSE DRUG REACTIONS