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Multiclass SVMs are usually implemented by combining several two-class SVMs. The one-versus-all method using winner-takes-all strategy and the one-versus-one method implemented by max-wins voting are popularly used for this purpose. In this paper we give empirical evidence to show that these methods are inferior to another one-versus-one method: one that(More)
Choosing optimal hyperparameters for support vector machines is an important step in SVM design. This is usually done by minimizing either an estimate of generalization error or some other related performance measures. In this paper, we empirically study the usefulness of several simple performance measures that are very inexpensive to compute. The results(More)
Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs of human tissue CD141(hi)XCR1⁺ CLEC9A⁺ DCs and CD1c⁺ DCs are murine CD103⁺ DCs and CD64⁻ CD11b⁺ DCs. In addition, human tissues also contain CD14⁺ cells, currently designated as DCs, with an(More)
Sepsis is characterized by a dysregulated inflammatory response to infection. Despite studies in mice, the cellular and molecular basis of human sepsis remains unclear and effective therapies are lacking. Blood monocytes serve as the first line of host defense and are equipped to recognize and respond to infection by triggering an immune-inflammatory(More)
Feature selection is a commonly addressed problem in classification. In gene expression-based cancer classification, a large number of genes in conjunction with a small number of samples makes the gene selection problem more important but also more challenging. Support vector machine as a popular classification algorithm, has been successfully used in(More)
In this paper, we propose a multi-category classification method that combines binary classifiers through soft-max function. Pos-teriori probabilities are also obtained. Both, one-versus-all and one-versus-one classifiers can be used in the combination. Empirical comparison shows that the proposed method is competitive with other implementations of(More)
Human dendritic cells (DCs) regulate the balance between immunity and tolerance through selective activation by environmental and pathogen-derived triggers. To characterize the rapid changes that occur during this process, we analyzed the underlying metabolic activity across a spectrum of functional DC activation states, from immunogenic to tolerogenic. We(More)
We studied two cancer classification problems with mass spectrometry data and used SVM-RFE to select a small subset of peaks as input variables for the classification. Our study shows that, SVM-RFE can select a good small subset of peaks with which the classifier achieves high prediction accuracy and the performance is much better than with the feature(More)