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Multiclass SVMs are usually implemented by combining several two-class SVMs. The one-versus-all method using winner-takes-all strategy and the one-versus-one method implemented by max-wins voting are popularly used for this purpose. In this paper we give empirical evidence to show that these methods are inferior to another one-versus-one method: one that(More)
Choosing optimal hyperparameters for support vector machines is an important step in SVM design. This is usually done by minimizing either an estimate of generalization error or some other related performance measures. In this paper, we empirically study the usefulness of several simple performance measures that are very inexpensive to compute. The results(More)
  • Naomi McGovern, Andreas Schlitzer, Merry Gunawan, Laura Jardine, Amanda Shin, Elizabeth Poyner +19 others
  • 2014
Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs of human tissue CD141(hi)XCR1⁺ CLEC9A⁺ DCs and CD1c⁺ DCs are murine CD103⁺ DCs and CD64⁻ CD11b⁺ DCs. In addition, human tissues also contain CD14⁺ cells, currently designated as DCs, with an(More)
In this paper, we propose a multi-category classification method that combines binary classifiers through soft-max function. Pos-teriori probabilities are also obtained. Both, one-versus-all and one-versus-one classifiers can be used in the combination. Empirical comparison shows that the proposed method is competitive with other implementations of(More)
We studied two cancer classification problems with mass spectrometry data and used SVM-RFE to select a small subset of peaks as input variables for the classification. Our study shows that, SVM-RFE can select a good small subset of peaks with which the classifier achieves high prediction accuracy and the performance is much better than with the feature(More)
The importance of monocyte-derived dendritic cells (DCs) is evidenced by the fact that they are essential for the elimination of pathogens. Although in vitro DCs can be generated by treatment of monocytes with GM-CSF and IL-4, it is unknown what stimuli induce differentiation of DCs in vivo. CD137L-DCs are human monocyte-derived DC that are generated by(More)
Wharton's jelly-derived Mesenchymal Stem Cells (MSCs) isolated from newborns with intrauterine fetal growth restriction were previously shown to exert anabolic features including insulin hypersensitivity. Here, we extend these observations and demonstrate that MSCs from small for gestational age (SGA) individuals have decreased mitochondrial oxygen(More)