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LC-MS/MS Determination and Pharmacokinetic Study of Dehydrocorydaline in Rat Plasma after Oral Administration of Dehydrocorydaline and Corydalis yanhusuo Extract
TLDR
The pharmacokinetic parameters showed that DHC from EFY was absorbed more rapidly and eliminated more slowly than pure DHC, which suggests that the differences might be due to the presence of P-glycoprotein (P-gp) inhibitors and that other alkaloids co-existing in the EFY may compete with DHC for transportation by P-gp, metabolization by P450, and binding to plasma proteins.
Identification of Metabolites of the Cardioprotective Alkaloid Dehydrocorydaline in Rat Plasma and Bile by Liquid Chromatography Coupled with Triple Quadrupole Linear Ion Trap Mass Spectrometry
TLDR
This is the first time that these metabolites of DHC have been identified in rat plasma and bile, which provides useful information for further analysis of the biotransformation of D HC and other quaternary protoberberine-type alkaloids.
[Identification and analysis of absorbed components in rat plasma after oral administration of active fraction of Corydalis yanhusuo by LC-MS/MS].
TLDR
The constituents absorbed into blood and the possible metabolites which demonstrate to originate from the active fraction of Corydalis yanhusuo are responsible for the observed efficacy.
IDENTIFICATION AND DETERMINATION OF THE MAJOR CONSTITUENTS IN AN ANTIANGIOGENESIS HERBAL FORMULA, QING-LUO-FANG, BY HPLC—DAD—ESI/MS
A high-performance liquid chromatography—diode array UV detection—electrospray ionization tandem mass spectrometry (HPLC—DAD—ESI-MS) method was established for the simultaneous qualitative and
[Identification of foliumn pyrrosiae from different habitats and species by HPLC fingerprint].
TLDR
The HPLC fingerprint method is stable and reliable with a good reproducibility and provides a reference standard for identifying Folium Pyrrosiae from different habitats and species.
[Determination of chlorogenic acid and mangiferin in Folium Pyrrosiae from different habitats and species by HPLC].
TLDR
An HPLC method for simultaneous determination of chlorogenic acid and mangiferin in original medicinal materials and decoction pieces of Pyrrosiae Folium was developed and was simple, reproducible and valid.