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The Microprocessor complex mediates the genesis of microRNAs
In vivo knock-down and in vitro reconstitution studies revealed that both components of this smaller complex, termed Microprocessor, are necessary and sufficient in mediating the genesis of miRNAs from the primary miRNA transcript.
Demethylation of H3K27 Regulates Polycomb Recruitment and H2A Ubiquitination
It is shown that human UTX, a member of the Jumonji C family of proteins, is a di- and trimethyl H3K27 demethylase, and a concerted mechanism for transcriptional activation in which cycles of H3k4 methylation by MLL2/3 are linked with the demethylation of H 3K27 through UTX.
The LIM Protein AJUBA Recruits Protein Arginine Methyltransferase 5 To Mediate SNAIL-Dependent Transcriptional Repression
The identification of the protein arginine methyltransferase 5 (PRMT5) as an effector recruited to SNAil through an interaction with AJUBA that functions to repress the SNAIL target gene, E-cadherin is described.
iNKT cell development is orchestrated by different branches of TGF-β signaling
It is demonstrated that TGF-β signaling carefully and specifically orchestrates several steps of iNKT cell development, including the maturation stage that is initially repressed by a Tif-1γ/Smad4-independent branch.
Transcription intermediary factor 1γ is a tumor suppressor in mouse and human chronic myelomonocytic leukemia.
It is demonstrated that Tif1G is an epigenetically regulated tumor suppressor gene in hematopoietic cells and suggested that changes in TIF1γ expression may be a biomarker of response to demethylating agents in CMML.
Negative control of Smad activity by ectodermin/Tif1γ patterns the mammalian embryo
It is unveiled that intracellular negative control of Smad function by ectodermin/Tif1γ is a crucial element in the cellular response to TGFβ signals in mammalian tissues.
Inactivation of TIF1γ Cooperates with KrasG12D to Induce Cystic Tumors of the Pancreas
It is suggested that Tif1γ is critical for tumor suppression in the pancreas, brings new insight into the genetics of pancreatic cancer, and constitutes a promising model to decipher the respective roles of SMAD4 and TIF1γ in the multifaceted functions of TGFβ in carcinogenesis and development.
Molecular cloning, genomic structure, and expression analysis of the mouse transcriptional intermediary factor 1 gamma gene.
Calcium‐binding protein immunoreactivity characterizes the auditory system of Gekko gecko
AB antibodies against the calcium‐binding proteins calretinin (CR), parvalbumin (PV), and calbindin‐D28k (CB) were used to characterize the gecko auditory system and showed that these antibodies are specific to gecko brain.