Kai Wang

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Serine phosphorylation of AMPA receptor (AMPAR) subunits GluA1 and GluA2 modulates AMPAR trafficking during long-term changes in strength of hippocampal excitatory transmission required for normal learning and memory. The post-translational addition and removal of O-linked β-N-acetylglucosamine (O-GlcNAc) also occurs on serine residues. This, together with(More)
Tuberculosis is a major global public health problem, which also affects economic and social development. China has the second largest burden of tuberculosis in the world. The tuberculosis morbidity in Xinjiang is much higher than the national situation; therefore, there is an urgent need for monitoring and predicting tuberculosis morbidity so as to make(More)
AIMS A better understanding of the ionic mechanisms for cardiac automaticity can lead to better strategies for engineering bio-artificial pacemakers. Here, we attempted to better define the relative contribution of I(f) and I(K1) in the generation of spontaneous action potentials (SAPs) in cardiomyocytes (CMs). METHODS AND RESULTS Monolayers of neonatal(More)
If (or Ih), encoded by the hyperpolarization-activated, cyclic nucleotide-gated (HCN1-4) channel gene family, contributes significantly to cardiac pacing. Bradycardic agents such as ZD7288 that target HCN channels have been developed, but the molecular configuration of their receptor is poorly defined. Here, we probed the drug receptor by systematically(More)
BACKGROUND Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes public health problems in Asian countries. Only a limited number of JEV-infected individuals show symptoms and develop severe encephalitis, indicating host-dependent susceptibilities. METHODOLOGY/PRINCIPAL FINDINGS C3H/HeN and DBA/2 mice, which exhibit different(More)
Yeast prions are self-perpetuating protein aggregates that cause heritable and transmissible phenotypic traits. Among these, [PSI+] and [URE3] stand out as the most studied yeast prions, and result from the self-assembly of the translation terminator Sup35p and the nitrogen catabolism regulator Ure2p, respectively, into insoluble fibrillar aggregates.(More)
OBJECTIVES To investigate the incidence rates and risk factors for catheter-related complications in different districts and populations in Henan Province in China. DESIGN Cross-sectional. SETTING Fourteen hospitals in Henan Province. PARTICIPANTS 865 patients with renal dysfunction undergoing dialysis using catheters between October 2013 and October(More)
Revelation of emerging exotic states of topological insulators (TIs) for future quantum computing applications relies on breaking time-reversal symmetry and opening a surface energy gap. Here, we report on the transport response of Bi2Te3 TI thin films in the presence of varying Cr dopants. By tracking the magnetoconductance (MC) in a low doping regime we(More)
Target of Rapamycin (TOR) is an eukaryotic protein kinase and evolutionally conserved from the last eukaryotic common ancestor (LECA) to humans. The growing evidences have shown that TOR signaling acts as a central controller of cell growth and development. The downstream effectors of TOR have been well-identified in yeast and animals by using the(More)
The abuse of antibiotics has led to the emergence of many resistant bacteria, which threaten public health on a global scale. Conventional pipelines for antibiotic discovery are gradually exhausted. Here a combinatorial yeast overlay method is presented for the isolation of antibacterial oligopeptides. Three antibacterial dipeptide and tripeptides were(More)