Kai-Sheng Liu

Publications13
h-index8
Citations242
Highly Influential Citations12
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SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells.
SNX-2112 is an Hsp90 inhibitor which is currently undergoing multiple phase 1 clinical trials; however, its mechanism of action needs to be further elaborated. Here we investigated the effects of… Expand
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SNX-2112, a Novel Hsp90 Inhibitor, Induces G2/M Cell Cycle Arrest and Apoptosis in MCF-7 Cells
SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor with anticancer properties currently in clinical trials. This study investigated the effects of SNX-2112 on inhibition of cell growth, the cell… Expand
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Cytotoxic dihydrothiophene-condensed chromones from the marine-derived fungus Penicillium oxalicum.
Two new dihydrothiophene-condensed chromones and a new natural chromone, namely oxalicumones A-C (1-3), respectively, were isolated from a culture broth of a marine-derived fungus, Penicillium… Expand
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The heat shock protein 90 inhibitor SNX-2112 inhibits B16 melanoma cell growth in vitro and in vivo.
SNX-2112 is a selective heat shock protein 90 (Hsp90) inhibitor which can exert a potent anticancer activity. In this study, we investigated the effects of SNX-2112 on B16… Expand
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Cytotoxic dihydrothiophene-condensed chromones from marine-derived fungus Penicillium oxalicum.
Two new dihydrothiophene-condensed chromones and a new natural chromone, namely oxalicumones A-C (1-3), respectively, were isolated from a culture broth of a marine-derived fungus Penicillium… Expand
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Indole alkaloids from marine-derived fungus Aspergillus sydowii SCSIO 00305
Marine microorganisms have proved to be an important source of pharmacologically active metabolites, and a growing number of marine-derived fungi have been reported to produce metabolites with unique… Expand
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The selective Hsp90 inhibitor BJ-B11 exhibits potent antitumor activity via induction of cell cycle arrest, apoptosis and autophagy in Eca-109 human esophageal squamous carcinoma cells.
BJ-B11 is a selective heat shock protein 90 (Hsp90) inhibitor that has been reported to possess significant antitumor activity in multiple types of cancer cells; however, the mechanism of action… Expand
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Two unique antiferromagnetic 3D frameworks with unusual CuII4 cluster and alternate CuII4 + CuII1 structural motif tuned by aromatic polycarboxylate coligand
Two new 3-amino-1,2,4-triazole (amtrz)-based 3D MOFs, [Cu4(amtrz)2(μ3-OH)2(btc)2]n (1), and [Cu5(amtrz)2(H2O)2(μ3-OH)2(btec)2]n (2) (btc3− = 1,3,5-benzenetricarboxylate and btec4− =… Expand
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The selective Hsp 90 inhibitor BJ-B 11 exhibits potent antitumor activity via induction of cell cycle arrest , apoptosis and autophagy in Eca-109 human esophageal squamous carcinoma cells
BJ-B11 is a selective heat shock protein 90 (Hsp90) inhibitor that has been reported to possess significant antitumor activity in multiple types of cancer cells; however, the mechanism of action… Expand
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Steroids from the South China Sea Gorgonian Coral Muricella flexuosa
Four new steroidal glycosides and a new steriod linked with a 4-hydroxyphenylmethylene group, namely muricellasteroids A- E (1 - 5), together with one known steroidal glycoside analog,… Expand
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