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OBJECTIVE Hemophilia B is caused by coagulation defects in the factor IX gene located in Xq27.1 on the X chromosome. A wide range of mutations, showing extensive molecular heterogeneity, have been described in hemophilia B patients. Our study was aimed at genetic analysis and prenatal diagnosis of hemophilia B in order to further elucidate the pathogenesis(More)
OBJECTIVE This study reevaluated the secular trends of blood pressure and hypertension prevalence in Chinese children and adolescents by adjusting for growing body sizes. METHODS The study population was from the China Health and Nutrition Survey (1991-2011) and included 7358 boys and 6881 girls aged 8-17 years. Body size measurements and blood pressure(More)
Birth defects are structural and/or functional malformations present at birth that cause physical or mental disability and are important public health problems. Our study was aimed at genetic analysis and prenatal diagnosis of congenital anomalies to understand the cause of certain birth defects. Karyotypes and array-comparative genomic hybridization (aCGH)(More)
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