Kai Mithoefer

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OBJECTIVE To provide a clear terminology and classification of muscle injuries in order to facilitate effective communication among medical practitioners and development of systematic treatment strategies. METHODS Thirty native English-speaking scientists and team doctors of national and first division professional sports teams were asked to complete a(More)
Antimycin A, KCN, and 1-methyl-4-phenylpyridinium ion (MPP+) all produced a marked depletion of cellular GSH levels in freshly isolated hepatocytes. This effect was consistently observed before the onset of cytotoxicity and seemed to be correlated with the loss of cellular ATP induced by these mitochondrial poisons. Concentrations of GSSG remained unchanged(More)
To investigate the debated role of intracellular trypsinogen activation and its relation to lysosomal enzyme redistribution in the pathogenesis of acute pancreatitis, rats were infused with the cholecystokinin analog caerulein at 5 micrograms.kg-1.h-1 for intervals up to 3 h, and the changes were contrasted with those in animals receiving saline or 0.25(More)
Articular cartilage lesions in the athletic population are observed with increasing frequency and, due to limited intrinsic healing capacity, can lead to progressive pain and functional limitation over time. If left untreated, isolated cartilage lesions can lead to progressive chondropenia or global cartilage loss over time. A chondropenia curve is(More)
The operative management of focal chondral lesions continues to be problematic for the treating orthopedic surgeon secondary to the limited regenerative capacity of articular cartilage. Although many treatment options are currently available, none fulfills the criteria for an ideal repair solution, including a hyaline repair tissue that completely fills the(More)
OBJECTIVE To summarize current clinical research practice and develop methodological standards for objective scientific evaluation of knee cartilage repair procedures and products. DESIGN A comprehensive literature review was performed of high-level original studies providing information relevant for the design of clinical studies on articular cartilage(More)
BACKGROUND Owing to the complexity and heterogeneity of muscle injuries, a generally accepted classification system is still lacking. AIMS To prospectively implement and validate a novel muscle injury classification and to evaluate its predictive value for return to professional football. METHODS The recently described Munich muscle injury(More)
Articular cartilage injury is prevalent in football players and results from chronic joint stress or acute traumatic injuries. Articular cartilage injury can often result in progressive painful impairment of joint function and limit sports participation. Management of articular cartilage injury in athletes aims to return the player to competition, and(More)
Microfracture is frequently used for articular cartilage repair in athletes. This study aimed to define the strength and weaknesses of this minimally invasive cartilage repair technique in the athletic population in an effort to optimize indications, functional outcome, and athletic participation after microfracture in the athlete's knee. A systematic(More)
The game of football, as it is called worldwide, is played by more than 300 million people globally. It is the most popular sport in the world, and participation in this dynamic sport is growing rapidly. We will from this point forward refer to the football athlete as a football (soccer) player for the importance of convention. The inherent nature of the(More)