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Nuclear movement is critical during neurogenesis and neuronal migration, which are fundamental for mammalian brain development. Although dynein, Lis1, and other cytoplasmic proteins are known for their roles in connecting microtubules to the nucleus during interkinetic nuclear migration (INM) and nucleokinesis, the factors connecting dynein/Lis1 to the(More)
Nuclear movement relative to cell bodies is a fundamental process during certain aspects of mammalian retinal development. During the generation of photoreceptor cells in the cell division cycle, the nuclei of progenitors oscillate between the apical and basal surfaces of the neuroblastic layer (NBL). This process is termed interkinetic nuclear migration(More)
How the nuclei in mammalian skeletal muscle fibers properly position themselves relative to the cell body is an interesting and important cell biology question. In the syncytial skeletal muscle cells, more than 100 nuclei are evenly distributed at the periphery of each cell, with 3-8 nuclei anchored beneath the neuromuscular junction (NMJ). Our previous(More)
The DNA damage response (DDR) and DNA repair are critical for maintaining genomic stability and evading many human diseases. Recent findings indicate that accumulation of SUN1, a nuclear envelope (NE) protein, is a significant pathogenic event in Emery-Dreifuss muscular dystrophy and Hutchinson-Gilford progeria syndrome, both caused by mutations in LMNA.(More)
Microblogs contain the most up-to-date and abundant opinion information on current events. Aspect-based opinion mining is a good way to get a comprehensive summarization of events. The most popular aspect based opinion mining models are used in the field of product and service. However, existing models are not suitable for event mining. In this paper we(More)
Using a large consortium of undergraduate students in an organized program at the University of California, Los Angeles (UCLA), we have undertaken a functional genomic screen in the Drosophila eye. In addition to the educational value of discovery-based learning, this article presents the first comprehensive genomewide analysis of essential genes involved(More)
As the rising applications of Named Data Networking (NDN) continue to increase the demand on network bandwidth, developing effective congestion mechanisms has become one of the high-priority research tasks for NDN architecture. This paper explores rate control protocol (RCP), a unique hop-by-hop feature in NDN routing, and one-to-one relationship between(More)
Content-Centric Networking (CCN) is a predominant substitute of the current TCP/IP networking and it is proposed to be the next generation Internet foundation. The evident characteristic of this network architecture is caching and indexing contents by the inner nodes - the routers, so as to reduce the redundant transmission and thereby shorten the distance(More)