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BACKGROUND The results of pediatric renal transplantation have improved markedly in the last decade. However, a number of relevant clinical problems remain, such as organ damage caused by chronic rejection, long-term toxicity of immunosuppressive therapy, difficulty in developing tolerance-inducing protocols, secondary cardiovascular comorbidity,(More)
With the Windows Phone 7 Microsoft will release a new mobile operating system this fall. By displaying ECG recordings and vital signs on this new platform it could be shown that devices with the new mobile operating system can be used as mobile monitoring units. Due to their multiple wireless communication capabilities they can be useful for the mobile(More)
INTRODUCTION Data on the efficacy and safety of everolimus in pediatric renal transplantation compared to other immunosuppressive regimens are scarce. PATIENTS/METHODS We therefore performed a multicenter, observational, matched cohort study over 4 years post-transplant in 35 patients on everolimus plus low-dose cyclosporine, who were matched (1:2) with a(More)
BACKGROUND Cytomegalovirus (CMV) replication and disease, with its associated morbidity and poor transplant outcome, represents a serious threat to transplant recipients. The pediatric kidney transplant population is at a particularly increased risk of CMV infection. METHODS We therefore analyzed CMV epidemiology in a large cohort of pediatric renal(More)
Patient registries are a useful tool to measure outcomes and compare the effectiveness of therapies in a specific patient population. High data quality and completeness are therefore advantageous for registry analysis. Data integration from multiple sources may increase completeness of the data. The pediatric renal transplantation registry CERTAIN(More)
Dyslipidemia contributes to cardiovascular morbidity and mortality in pediatric transplant recipients. Data on prevalence and risk factors in pediatric cohorts are, however, scarce. We therefore determined the prevalence of dyslipidemia in 386 pediatric renal transplant recipients enrolled in the CERTAIN registry. Data were obtained before and during the(More)
In order to investigate the hypothesis that the mammalian target of rapamycin inhibitor everolimus (EVR) shows anticytomegalovirus (CMV) activity in pediatric patients, we analyzed the impact of EVR-based immunosuppressive therapy on CMV replication and disease in a large cohort (n = 301) of pediatric kidney allograft recipients. The EVR cohort (n = 59),(More)
Die klinische und die epidemiologische Forschung an seltenen Krankheiten sind wegen der geringen Fallzahlen schwierig. Eine flächendeckende Zusammenführung von Daten und Informationen in Registern soll diese Situation verbessern. Zu diesem Zweck wurde vom Arbeitskreis „Nierentransplantation im Kindes- und Jugendalter“ der Gesellschaft für Pädiatrische(More)
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