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Oesophageal cancer is one of the most aggressive cancers and is the sixth leading cause of cancer death worldwide. Approximately 70% of global oesophageal cancer cases occur in China, with oesophageal squamous cell carcinoma (ESCC) being the histopathological form in the vast majority of cases (>90%). Currently, there are limited clinical approaches for the(More)
Modern multiprocessor embedded systems execute a large number of tasks on shared processors and handle their complex communications on shared communication networks. Traditional methods from the HW/SW codesign or general purpose computing domain cannot be applied any more to cope with this new class of complex systems. To overcome this problem, a framework(More)
Energy consumption has become an important issue for modern embedded systems. This is because, one does not only like to deploy high-performance systems and provide guaranteed services, but also request system deployments to last as long as possible. With online dynamic power management (DPM), one adaptively changes the system's power mode, i.e., schedules(More)
As single-processor systems are ceasing to scale effectively, multi-processor systems are becoming more and more popular. While there are many challenges of designing multi-processor systems in hardware, writing efficient parallel applications that utilize the computing capability of multiple processors may reveal to be even more challenging. In this paper,(More)
Power dissipation has been an important design issue for a wide range of computer systems in the past decades. Dynamic power consumption due to signal switching activities and static power consumption due to leakage current are the two major sources of power consumption in a CMOS circuit. As CMOS technology advances towards deep sub-micron domain, static(More)
Effective power management is an important design concern for modern embedded systems. In this paper, we present an effective framework to integrate both DVS and DPM to optimize the overall energy consumption. We propose an online algorithm to determine the optimal operating frequency and mode transition of a processor based on the runtime workload. Our(More)
β-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of the Wnt signaling pathway as it relates to β-catenin signaling in(More)
Protein tyrosine phosphatase 1B (PTP1B) is a promising therapeutic target for type 2 diabetes. Herein, we report the evolution of a previously identified 3-phenylpropanoic acid-based PTP1B inhibitor to an orally active lead compound. A series of 3-phenylpropanoic acid-based PTP1B inhibitors were synthesized, and three of them,(More)
Snake-venom thrombin-like enzymes (SVTLEs) are serine proteases that are widely distributed in snakes from the Crotalinae subfamily of the Viperidae. In contrast to other snake-venom serine proteases, they have a biochemical activity similar to that of thrombin and play an important role in the process of blood coagulation. However, SVTLEs cannot activate(More)
In the present study, we aimed to evaluate the protective effect of sesamin on kidney damage and renal endothelial dysfunction in two-kidney, one-clip renovascular hypertensive rats fed with a high-fat-sucrose diet (2K1C rats on HFS diet). Sesamin was intragastrically administered to 2K1C rats on HFS diet for eight weeks. Then, we measured the levels of(More)