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Crystal structure of a platelet-agglutinating factor isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus).
A tetrameric platelet-agglutinating factor, termed mucrocetin, purified from the venom of Taiwan habu, appears to provide a useful tool to study platelet agglutination by binding to the GPIb-IX-V complex. Expand
Cloning, characterization and mutagenesis of Russell's viper venom L-amino acid oxidase: Insights into its catalytic mechanism.
A direct hydride transfer from substrate to FAD as the mechanism for SV-LAAOs is suggested, and apparently, DrLAO may synergize with other venom components to prolong and enhance bleeding symptoms after Daboia envenoming. Expand
The crystal structure of XC1258 from Xanthomonas campestris: A putative procaryotic Nit protein with an arsenic adduct in the active site
The crystal structure of XC1258 from Xanthomonas campestris: A putative procaryotic Nit protein with an arsenic adduct in the active site Ko-Hsin Chin, Ying-Der Tsai, Nei-Li Chan, Kai-Fa Huang,Expand
Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors
Aldehyde‐containing peptidomimetics were identified to be potent inhibitors against MERS‐CoV 3CLpro and these compounds exhibited good selectivity index and could lead to the development of broad‐spectrum antiviral drugs against emerging CoVs and picornaviruses. Expand
Structures of Human Golgi-resident Glutaminyl Cyclase and Its Complexes with Inhibitors Reveal a Large Loop Movement upon Inhibitor Binding*
Comparisons of the inhibitor-bound structures revealed distinct interactions of the inhibitors with gQC and sQC, which are consistent with the results from the inhibitor assays reported here, and suggest the different inhibitor binding modes allow the design of specific inhibitors toward gQ C and s QC. Expand
The N-Terminal Amphipathic Helix of the Topological Specificity Factor MinE Is Associated with Shaping Membrane Curvature
It is reported that MinE-induced membrane deformation involves the formation of an amphipathic helix of MinE2–9, which, together with the adjacent basic residues, function as membrane anchors, which appear to affect membrane curvature. Expand
Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation.
The structure of human QC in free form and bound to a substrate and three imidazole-derived inhibitors is presented and a catalysis mechanism of the formation of protein N-terminal pGlu is proposed. Expand
Determinants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analogues.
High-resolution crystal structures of a SVMP from Taiwan habu cocrystallized with the endogenous inhibitors suggest a close correlation between the inhibitory activity of an inhibitor and its ability to fill the S-1 pocket of the proteinase, and may provide insights into the rational design of small molecules that bind to this class of zinc-metalloproteinases. Expand
A Multivalent Marine Lectin from Crenomytilus grayanus Possesses Anti-cancer Activity through Recognizing Globotriose Gb3.
Analysis of the crystal CGL structures bound to galactose, galactosamine, and globotriose Gb3 indicated that each CGL can bind three ligands through a carbohydrate-binding motif involving an extensive histidine- and water-mediated hydrogen bond network. Expand
Cloning, expression, characterization, and crystallization of a glutaminyl cyclase from human bone marrow: a single zinc metalloenzyme.
The cloning of a QC cDNA from human bone marrow cDNA library is presented, and an atomic absorption analysis demonstrated that human QC contains one zinc ion per protein molecule, which belongs to cubic, tetragonal, and rhombohedral forms. Expand