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Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation.
Highly active antiretroviral therapy (HAART) suppresses HIV-1 replication but cannot eliminate the virus because HIV-1 establishes latent infection. Interruption of HAART leads to a rapid rebound ofExpand
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Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection
During chronic viral infection, virus-specific CD8+ T cells become exhausted, exhibit poor effector function and lose memory potential. However, exhausted CD8+ T cells can still contain viralExpand
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Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations
Despite antiretroviral therapy (ART), human immunodeficiency virus (HIV)-1 persists in a stable latent reservoir, primarily in resting memory CD4+ T cells. This reservoir presents a major barrier toExpand
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Efficient Production of Mice from Embryonic Stem Cells Injected into Four‐ or Eight‐Cell Embryos by Piezo Micromanipulation
The conventional method for producing embryonic stem (ES) cell‐derived knockout or transgenic mice involves injection of ES cells into normal, diploid blastocysts followed by several rounds ofExpand
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Transcriptional Reprogramming during Effector‐to‐Memory Transition Renders CD4+ T Cells Permissive for Latent HIV‐1 Infection
&NA; The latent reservoir for HIV‐1 in resting memory CD4+ T cells is the major barrier to curing HIV‐1 infection. Studies of HIV‐1 latency have focused on regulation of viral gene expression inExpand
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TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb
Comprehensively elucidating the molecular mechanisms of human immunodeficiency virus type 1 (HIV-1) latency is a priority to achieve a functional cure. As current 'shock' agents failed to efficientlyExpand
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Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor
According to the World Health Organization (WHO) newly updated situation report on March 18th, 2020, the coronavirus disease 2019 (COVID-19) pandemic has confirmed 191,127 cases and claimed 7807Expand
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Complete biosynthesis of cannabinoids and their unnatural analogues in yeast
Cannabis sativa L. has been cultivated and used around the globe for its medicinal properties for millennia1. Some cannabinoids, the hallmark constituents of Cannabis, and their analogues have beenExpand
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CD161+ CD4+ T Cells Harbor Clonally Expanded Replication-Competent HIV-1 in Antiretroviral Therapy-Suppressed Individuals
The latent reservoir continues to be the major obstacle to curing HIV-1 infection. The clonal expansion of latently infected cells adds another layer maintaining the long-term stability of theExpand
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X4-Tropic Latent HIV-1 Is Enriched in Peripheral Follicular Helper T Cells and Is Correlated with Disease Progression
TFH cells have been shown to harbor a significant amount of latent HIV-1; however, the viral characteristics of this reservoir and its clinical relevance remain largely unknown. In this study, weExpand
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