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Activity of Novel Synthetic Peptides against Candida albicans
Peptides demonstrated low haemolytic activity but significant toxicity on two normal human epithelial cell lines and showed synergistic effects when used in combination with conventional antifungals when the therapeutic application of the peptides is limited.
Capillasterin A, a Novel Pyrano[2,3-f]chromene from the Australian Crinoid Capillaster multiradiatus
This is the first report of a natural product that contains the pyrano[2,3-f]chromene skeleton and compounds 2–6 were observed to display moderate inhibition of in vitro HIV-1 replication in a T cell line with EC50 values ranging from 7.5 to 25.5 µM without concomitant cytotoxicity.
Comatulins A-E, Taurine-Conjugated Anthraquinones from the Australian Crinoid Comatula rotalaria.
The first X-ray crystal structure of a crinoid-derived acyl anthraquinone, rhodocomatulin 5,7-dimethyl ether, is reported here, and showed an inhibitory effect on larval motility and development and induced the eviscerated (Evi) phenotype.
High Throughput Screening of the NatureBank ‘Marine Collection’ in a Haemonchus Bioassay Identifies Anthelmintic Activity in Extracts from a Range of Sponges from Australian Waters
Results indicate that a range of sponge species from Australian waters represents a rich source of natural compounds with nematocidal or nematostatic properties, and a set of 29 sponge samples for future chemical investigation is prioritised.
Chemical and Biological Investigations of Australian Crinoids
The main aim of this PhD project was to identify new chemistry from crinoids sourced from Australian waters and subsequently screen the isolated compounds in a variety of biological assays.
Dysidenin from the Marine Sponge Citronia sp. Affects the Motility and Morphology of Haemonchus contortus Larvae In Vitro.
High-throughput screening of the NatureBank marine extract library (n = 7616) using a phenotypic assay for the parasitic nematode Haemonchus contortus identified an active extract derived from the
Synthesis of New Triazolopyrazine Antimalarial Compounds
A radical approach to late-stage functionalization using photoredox and Diversinate™ chemistry on the Open Source Malaria (OSM) triazolopyrazine scaffold (Series 4) resulted in the synthesis of 12