Kaberi Das-Panja

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The protective impact of exercise on neurodegenerative processes has not been confirmed, and the mechanisms underlying the benefit of exercise have not been determined in human Parkinson's disease or in chronic animal disease models. This research examined the long-term neurological, behavioral, and mechanistic consequences of endurance exercise in(More)
BACKGROUND AND PURPOSE Dopamine is a major regulator of sodium reabsorption in proximal tubule epithelia. By binding to D1-receptors, dopamine induces endocytosis of plasma membrane Na,K-ATPase, resulting in a reduced capacity of the cells to transport sodium, thus contributing to natriuresis. We have previously demonstrated several aspects of the molecular(More)
Modulation of enzyme activity by inhibition and activation plays an important physiological role in regulation of cellular metabolism. Compared to the wealth of information available regarding inhibition of metabolic pathways, little is known about activation. Limited proteolysis of zymogens exemplifies irreversible activation. Reversible activation may(More)
The ATP-dependent phosphorylation of riboflavin to FMN by flavokinase from Vigna radiata was activated by orthophosphate (Pi) in a concentration dependent manner. Pi affected both the K(m) and Vmax, indicating that it is a non-essential, mixed type activator. The extent of activation by Pi was dependent on the cation (Mg2+ or Zn2+). Activation by other(More)
Partitioning is a common procedure for the separation of two solutes from a solution based on their differential solubility in an immiscible solvent. This has been widely used to quantitate riboflavin, flavin mononucleotide (FMN), and flavin adenine dinucleotide in aqueous samples by extraction with water-saturated benzyl alcohol. Here we report that the(More)
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