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OBJECTIVES The safety and efficacy of early acetylcholinesterase inhibitors therapy in patients with cognitive impairment no dementia (CIND) after a cerebrovascular accident have not been examined. In this study, we investigated the safety and efficacy of rivastigmine in cognition, particularly executive function in patients with CIND because of(More)
BACKGROUND The utility of poststroke cognitive status, namely dementia, cognitive impairment no dementia (CIND), mild cognitive impairment (MCI), and no cognitive impairment (NCI), in predicting dementia has been previously examined. However, no studies to date have compared the ability of subtypes of MCI and CIND to predict dementia in a poststroke(More)
BACKGROUND/AIMS Our objective was to characterize the cognitive profile of patients with mild Alzheimer's disease (AD) and subcortical ischemic vascular dementia (SIVD) matched using a functional scale. METHODS AD and SIVD were diagnosed using the NINCDS-ADRDA and the criteria proposed by Erkinjuntti et al., respectively. The Clinical Dementia Rating(More)
BACKGROUND/AIMS Previous work combining the Mini-Mental State Examination (MMSE) and Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) has been conducted in western populations. We ascertained, in an Asian population, (1) the best method of combining the tests, (2) the effects of educational level, and (3) the effect of different dementia(More)
BACKGROUND Population-based studies have demonstrated the association of inflammation and cognitive impairment. However, few studies to date have examined this association in ischemic stroke patients. AIMS The study aims to determine the association between inflammatory markers and cognitive impairment. METHODS Ischemic stroke patients with baseline(More)
BACKGROUND AND PURPOSE While recent studies have examined neuroimaging correlates of post-stroke mild cognitive impairment (MCI), no studies have examined neuroimaging correlates of post-stroke subjective cognitive impairment (SCI). METHODS Consecutive patients with magnetic resonance imaging-confirmed acute lacunar strokes at a tertiary institute were(More)
BACKGROUND AND PURPOSE There is some evidence that poststroke dementia, cognitive impairment no dementia (CIND), and mild cognitive impairment predict for poor outcomes such as dementia, death, and institutionalization. However, few studies have examined the prognostic value of CIND, CIND severity, and domain impairments in a poststroke cohort. METHODS A(More)
Background and Purpose—There is some evidence that poststroke dementia, cognitive impairment no dementia (CIND), and mild cognitive impairment predict for poor outcomes such as dementia, death, and institutionalization. However, few studies have examined the prognostic value of CIND, CIND severity, and domain impairments in a poststroke cohort. Methods—A(More)
BACKGROUND Platelet-derived growth factor (PDGF)-AB and BB have been shown to possess angiogenic properties in vivo, and decreased levels have been linked to plaque instability in atherosclerosis. Little work has been done to determine if PDGF is associated with outcomes after stroke, in particular cognitive outcomes. Therefore, in this sudy, we(More)
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