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  • Ailen M. Sanchez, George N. Bennett, Ka-Yiu San
  • Biology, Medicine
  • Metabolic engineering
  • 2005 (First Publication: 1 May 2005)
  • A novel in vivo method of producing succinate has been developed. A genetically engineered Escherichia coli strain has been constructed to meet the NADH requirement and carbon demand to produce highExpand
  • Christie A. M. Peebles, Erik Heller Hughes, Jacqueline V. Shanks, Ka-Yiu San
  • Medicine, Biology
  • Metabolic engineering
  • 2009 (First Publication: 1 March 2009)
  • Jasmonic acid (JA) activates the transcriptional regulator ORCA3, which has a role in regulating the terpenoid indole alkaloid (TIA) pathway within Catharanthus roseus. The TIA pathway leads to theExpand
  • Irene Toro Martinez, Jiangfeng Zhu, Henry K. Lin, George N. Bennett, Ka-Yiu San
  • Biology, Medicine
  • Metabolic engineering
  • 2008 (First Publication: 1 November 2008)
  • Reactions requiring reducing equivalents, NAD(P)H, are of enormous importance for the synthesis of industrially valuable compounds such as carotenoids, polymers, antibiotics and chiral alcohols amongExpand
  • Henry K. Lin, George N. Bennett, Ka-Yiu San
  • Biology, Medicine
  • Metabolic engineering
  • 2005 (First Publication: 1 March 2005)
  • The potential to produce succinate aerobically in Escherichia coli would offer great advantages over anaerobic fermentation in terms of faster biomass generation, carbon throughput, and productExpand
  • Henry K. Lin, George N. Bennett, Ka-Yiu San
  • Chemistry, Medicine
  • Biotechnology and bioengineering
  • 2005 (First Publication: 20 June 2005)
  • An aerobic succinate production system developed by Lin et al. (Metab Eng, in press) is capable of achieving the maximum theoretical succinate yield of 1.0 mol/mol glucose for aerobic conditions. ItExpand
  • Ailen M. Sanchez, George N. Bennett, Ka-Yiu San
  • Chemistry, Medicine
  • Biotechnology progress
  • 2005 (First Publication: 5 September 2008)
  • An adhE, ldhA double mutant Escherichia coli strain, SBS110MG, has been constructed to produce succinic acid in the presence of heterologous pyruvate carboxylase (PYC). The strategic design aims atExpand
  • Henry K. Lin, Ka-Yiu San, George N. Bennett
  • Biology, Medicine
  • Applied Microbiology and Biotechnology
  • 2004 (First Publication: 1 June 2005)
  • Sorghum vulgare phosphoenolpyruvate carboxylase (PEPC) and Lactococcus lactis pyruvate carboxylase (PYC) were overexpressed in Escherichia coli concurrently to improve the production of succinate, aExpand