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In this paper, three data hiding methods are proposed, based upon properties of DNA sequences. It is highlighted that DNA sequences possess some interesting properties which can be utilized to hide data. These three methods are: the Insertion Method, the Complementary Pair Method and the Substitution Method. For each method, a reference DNA sequence S is(More)
A protein function pair approach, based on protein-protein interaction (PPI) data, is proposed to predict protein functions. Randomization tests are performed on the PPI dataset, which resulted in a protein function correlation scoring value which is used to rank the relative importance of a function pair. It has been found that certain classes of protein(More)
The purpose of this study was to determine whether toll-like receptors 9 (TLR9) gene polymorphisms (rs352139 and rs352140) were markers of susceptibility to the development and progression of membranous nephropathy (MGN) in Taiwanese patients. The polymorphisms were investigated by polymerase chain reaction in 397 Taiwanese individuals (134 MGN patients and(More)
Many protein complexes prediction approaches are based on the assumptions that (i) protein complexes have dense protein-protein interactions (PPI) among their subunits, and (ii) high functional similarity for the subunits. We suggest to investigate those assumptions by studying the subunits' interaction topology and sequences identity. Such consideration(More)
Lung cancer is one of the leading causes of death in both the USA and Taiwan, and it is thought that the cause of cancer could be because of the gain of function of an oncoprotein or the loss of function of a tumour suppressor protein. Consequently, these proteins are potential targets for drugs. In this study, differentially expressed genes are identified,(More)
MicroRNAs are small, endogenous RNAs found in many different species and are known to have an influence on diverse biological phenomena. They also play crucial roles in plant biological processes, such as metabolism, leaf sidedness and flower development. However, the functional roles of most microRNAs are still unknown. The identification of closely(More)
Many proteins are known to be associated with cancer diseases. It is quite often that their precise functional role in disease pathogenesis remains unclear. A strategy to gain a better understanding of the function of these proteins is to make use of a combination of different aspects of proteomics data types. In this study, we extended Aragues's method by(More)