KV Anderson

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Work in the past decade has revealed that cilia and centro-somes, specialized microtubule-based organelles, can act as centers for developmental signaling pathways. It is now well-established that Sonic hedgehog (Shh) signaling depends on the primary cilium. Cilia are templated by the basal body, a specialized centrosomes, and it has been suggested that(More)
Bardet-Biedl syndrome (BBS) and Meckel-Gruber syndrome (MKS) are genetic disorders caused by disruption of primary cilia. The BBS and MKS proteins are found in two distinct protein complexes but the functional relationships between these two complexes are not clear. Here we analyze double mutant mouse embryos to define these relationships. Bbs4;Mks1 double(More)
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