KSH de Silva

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INTRODUCTION Childhood obesity is increasing in Sri Lanka. Obesity related morbidity is mainly associated with the metabolic syndrome (MetS) and non-alcoholic steatohepatitis (NASH). Recent studies have shown these serious health consequences in obese children. OBJECTIVES The objectives of our study were to document the presence of MetS and NASH in obese(More)
Cell lineages of the early human gonad commit to one of the two mutually antagonistic organogenetic fates, the testis or the ovary. Some individuals with a 46,XX karyotype develop testes or ovotestes (testicular or ovotesticular disorder of sex development; TDSD/OTDSD), due to the presence of the testis-determining gene, SRY Other rare complex syndromic(More)
OBJECTIVE To differentiate the clinical manifestations of a Group A beta haemolytic streptococcal throat infection from viral and other bacterial infections. SETTING Outpatients' department, Lady Ridgeway Hospital, Colombo. PATIENTS AND METHODS Children aged 3 to 12 years attending with a sore throat. Throat swabs were taken and relevant details were(More)
The objective of this study was to identify disease-causing mutations in a Sri Lankan male child presenting with ambiguous genitalia and psychomotor delay using the exome sequencing approach. A novel mutation in the aristaless-related homeobox (ARX) gene causing a hemizygous nucleotide substitution in exon 5 was identified (NM_139058.2 (ARX): c.1614G>T;(More)
INTRODUCTION The final examination in paediatrics for medical undergraduates in Sri Lanka consists of a written and a clinical component. Each candidate at the clinical component sees one long case and two short cases. OBJECTIVES To assess the views of the bystanders regarding their sick children participating at a clinical examination, and to evaluate(More)
INTRODUCTION Hepatitis A is a benign illness in children with the rare possibility of fatal complications. Although an endemic disease, very few studies have been done in children regarding the seroprevalence of hepatitis A antibodies in Sri Lanka. OBJECTIVES (i) To document the seropositivity for hepatitis A in a group of children admitted to a(More)
Samples of the muscle and liver of tilapia (Oreochromis mossambicus) obtained from the five reservoirs in four catchments in southern Sri Lanka in 1998 were analyzed for 16 elements: As, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Pb, Sr, and Zn by inductively coupled plasma emission spectrophotometry, and Hg by atomic absorption spectrophotometry. The(More)
OBJECTIVE To assess client satisfaction of bystanders regarding (a) outcome of the illness and treatment and (b) advice given regarding the illness and attitudes of doctors. DESIGN A descriptive cross-sectional study based on an interviewer administered questionnaire. SETTING A ward at Lady Ridgeway Children's Hospital, Colombo. STUDY SAMPLE The(More)
INTRODUCTION Recombinant human growth hormone (r-hGH) for growth hormone deficiency (GHD) has been available free in the state hospitals of Sri Lanka since 2009. OBJECTIVES The aims were to compare height standard deviation scores (SDS) before and after treatment and compare heights at final assessment in relation to the target height (TH) and TH range.(More)
Method A retrospective cohort study was performed on 205 children aged 1−12 years presented to a tertiary care hospital in Sri Lanka;119 with epilepsy, exposed to AEDs more than 2 years and 86 who are unexposed to AED. Vitamin D levels and bone profile were analyzed by chemiluminescent auto analyzer and photometric methods respectively. The prevalence of(More)