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Cell lineages of the early human gonad commit to one of the two mutually antagonistic organogenetic fates, the testis or the ovary. Some individuals with a 46,XX karyotype develop testes or ovotestes (testicular or ovotesticular disorder of sex development; TDSD/OTDSD), due to the presence of the testis-determining gene, SRY Other rare complex syndromic(More)
OBJECTIVE To assess client satisfaction of bystanders regarding (a) outcome of the illness and treatment and (b) advice given regarding the illness and attitudes of doctors. DESIGN A descriptive cross-sectional study based on an interviewer administered questionnaire. SETTING A ward at Lady Ridgeway Children's Hospital, Colombo. STUDY SAMPLE The(More)
INTRODUCTION Childhood obesity is increasing in Sri Lanka. Obesity related morbidity is mainly associated with the metabolic syndrome (MetS) and non-alcoholic steatohepatitis (NASH). Recent studies have shown these serious health consequences in obese children. OBJECTIVES The objectives of our study were to document the presence of MetS and NASH in obese(More)
INTRODUCTION Hepatitis A is a benign illness in children with the rare possibility of fatal complications. Although an endemic disease, very few studies have been done in children regarding the seroprevalence of hepatitis A antibodies in Sri Lanka. OBJECTIVES (i) To document the seropositivity for hepatitis A in a group of children admitted to a(More)
OBJECTIVE To differentiate the clinical manifestations of a Group A beta haemolytic streptococcal throat infection from viral and other bacterial infections. SETTING Outpatients' department, Lady Ridgeway Hospital, Colombo. PATIENTS AND METHODS Children aged 3 to 12 years attending with a sore throat. Throat swabs were taken and relevant details were(More)
INTRODUCTION Growth hormone releasing hormone receptor (GHRH-R) codon 72 mutation is recognised as a common genetic cause of growth hormone deficiency (GHD) in the Indian subcontinent resulting in a characteristic lean phenotype. Genetic studies have not been previously carried out in Sri Lankans with GHD. METHODS Patients with GHD presenting to a(More)
UNLABELLED Children rarely present with phaeochromocytoma. Their presentation differs from that of adults. The classic triad of sweating, headache and palpitation may not always present in children with phaeochromocytoma. In this study, we present a 6-year-old girl who came to us with polyuria and polydipsia for evaluation of suspected diabetes insipidus.(More)
INTRODUCTION There are several conditions giving rise to 46, XY disorders of sex development (DSD) with different modes of inheritance. Therefore definitive diagnosis based on molecular genetic confirmation would be the ideal to counsel parents regarding the future implications of the condition affecting their baby. This is the first report from Sri Lanka(More)