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SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis
Background SDZ ASM 981 is a selective inhibitor of the production of pro‐inflammatory cytokines from T cells and mast cells in vitro. It is the first ascomycin macrolactam derivative underExpand
Oral alitretinoin (9-cis-retinoic acid) therapy for chronic hand dermatitis in patients refractory to standard therapy: results of a randomized, double-blind, placebo-controlled, multicenter trial.
Alitretinoin given at well-tolerated doses induced substantial clearing of chronic hand dermatitis in patients refractory to conventional therapy. Expand
Identification of functional domains on human interleukin 10.
Two functional domains of IL-10 exerting differentIL-10 like activities are identified, an observation that suggests that relatively small segments of these signal proteins are responsible for particular biological functions. Expand
A continuous T-cell line from a patient with Sézary syndrome
The fact that the patient demonstrated no natural killer-cell or activated killer- cell activity against the Se-Ax cell line may in part explain the successful establishment of the continuous cell line from bulk culture. Expand
Dermatologic and oral findings in a cohort of 47 patients with Papillon-Lefèvre syndrome.
No significant correlation could be demonstrated between the level of periodontal infection and severity of skin affections, supporting the concept that these 2 major components of Papillon-Lefèvre syndrome are unrelated to each other. Expand
Construction and validation of a photographic guide for assessing severity of chronic hand dermatitis
This work has shown that a standardized instrument is needed to rate the overall severity of chronic hand dermatitis (CHD), in particular during clinical trials, and is likely to help improve the quality of clinical trials. Expand
Patch test reactivity to nickel alloys
11 widely used nickel alloys were investigated with respect to corrosion stability and reactivity in nickel‐sensitive individuals. Alloys with a nickel release in synthetic sweat exceeding 1Expand
Chemotaxis of human osteoblasts
The results show that TGF‐P andPDGF‐BB are important regulators of human osteoblast migration, but other growth factors IGF‐I, IGF‐II and PDGF‐AA may also stimulate osteobstroke migration and support a possible use of TGF'P and PD GF‐BB in growth factor‐induced osteogenesis. Expand
The Invitation
The Invitation is a Universities Pavillion which will be placed within the exhibition area of SIGGRAPH Asia 2010 and is expected to complement the Art Gallery and E-Tech Programs which are unfortunately not included in this year's conference. Expand
The delayed-type hypersensitivity reaction is dependent on IL-8. Inhibition of a tuberculin skin reaction by an anti-IL-8 monoclonal antibody.
It is found that the alpha-chemokine IL-8 plays an important pathophysiologic role for the development of a DTH reaction because infusion of a neutralizing anti-IL-8 mAb (WS-4) was able to suppress theDevelopment of a tuberculin skin reaction in rabbits. Expand